2013 Fiscal Year Final Research Report
The role of innate immune signals in controlling regulatory T cells
| Project/Area Number |
23390088
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University (2012-2013)
Dokkyo Medical University (2011) |
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Principal Investigator |
SAYURI Yamazaki 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (70567255)
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| Research Collaborator |
SEYA Tsukasa 北海道大学, 大学院・医学研究科免疫学 (10301805)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 制御性T細胞 / 樹状細胞 / Foxp3 / toll like receptor / 口腔 / 皮膚 |
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| Research Abstract |
We showed regulatory T cells that suppress important immune responses are expanded or induced by antigen presenting dendritic cells. Regulatory T cell is a promising therapy for autoimmunity, graft rejection and allergy. To develop an effective regulatory-T cell therapy, we studied followings. 1) What kinds of innate signals keep regulatory T cell survive long in vivo? 2) To suppress only unwanted responses, are there any innate signals that expand regulatory T cells specifically? We have found that TLR 2 signals that activate dendritic cells maintain regulatory T cell survival and function in vivo. We also found that dendritic cells from oral cavity induce regulatory T cells specifically. And, we are currently investigating a dendritic-cell activating signal that expands regulatory T cell up to about 60% of CD4+T cells in the skin.
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[Journal Article] Antigen delivery to CD11c^+ CD8^- dendritic cells induces protective immune response against experimental melanoma in mice in vivo2014
Author(s)
Neubert K, Lehmann C, Heger L, Baranska A, Staedtler A, Buchholz V, Yamazaki S, Heidkamp G, Eissing N, Zebroski H, Nussenzweig M, Nimmerjahn F, Dudziak D
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Journal Title
J Immunol
Volume: (in press)
DOI
Peer Reviewed
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