Regulatory mechanism of FDC activation via Fca/mR

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: HONDA Shinichiro 筑波大学, 医学医療系, 准教授 (60360640)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 濾胞樹状細胞 / IgM / Fc受容体

Research Abstract

Follicular dendritic cells (FDCs) capture and retain antigen for long period to activate cognate B cells, leading to germinal center formation. We established a novel method for FDCs isolation from lymphoid organs of naive mice. Surprisingly, analysis with this method showed that FDCs internalized capturing antigen via Fca/mR. Aa a result of this internalization, antigen amount on FDCs cells surface was decreased. These results suggested that Fca/mR regulates antigen amount on FDCs cell surface, leading to the regulation of B cells activation and germinal center formation.

Research Products

• [Journal Article] Involvement of Fcα/μR (CD351) in autoantibody production (2013)
  • Author(s): Yoshizawa Y, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 57(2) Pages: 216-219
  • DOI: 10.1016/j.molimm.2013.10.002
  • Peer Reviewed
• [Journal Article] Molecular characterization of the dimer formation of Fcα/μ receptor (CD351) (2013)
  • Author(s): Takagaki K, Satoh K, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 56(1-2) Pages: 23-27
  • DOI: 10.1016/j.molimm.2013.04.003
  • Peer Reviewed
• [Journal Article] Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells (2013)
  • Author(s): Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland E K, Li Q-Z, Miyazaki T
  • Journal Title: Cell Reports Volume: 3 Pages: 1-12
  • DOI: 10.1016/j.celrep.2013.03.006
  • Peer Reviewed
• [Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A
  • Journal Title: J Exp Med Volume: 209(8) Pages: 1493-1503
  • DOI: 10.1084/jem.20120096
  • Peer Reviewed
• [Journal Article] Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A
  • Journal Title: Biochem Biophy Res Comm Volume: 417(1) Pages: 646-650
  • DOI: 10.1016/j.bbrc.2011.12.025
  • Peer Reviewed
• [Journal Article] Isolation and characterization of naïve follicular dendritic cells (2012)
  • Author(s): Usui K, Honda S, Yoshizawa Y, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A
  • Journal Title: Mol Immunol Volume: 50(3) Pages: 172-176
  • DOI: 10.1016/j.molimm.2011.11.010
  • Peer Reviewed
• [Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses (2011)
  • Author(s): Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Nadia K. Tchao, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lewis L. Lanier, Shibuya A
  • Journal Title: J Exp Med Volume: 208(8) Pages: 1661-1671
  • DOI: 10.1084/jem.20101623
  • Peer Reviewed
• [Journal Article] Fcα/μ を介した免疫制御 (2011)
  • Author(s): 本多伸一郎, 渋谷 彰
  • Journal Title: 臨床免疫・アレルギー科 Volume: 55(5) Pages: 552-558
  • URL: http://www.kahyo.com/item/M201105-555
• [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis (2013)
  • Author(s): Totsuka N, Kim YG, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Shibuya K, Shibuya A
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2013-12-13
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2013-12-12
• [Presentation] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells (2013)
  • Author(s): Arai S, Honda S, Shibuya A, Li Q-Z, Miyazaki T
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2013-12-11
• [Presentation] Fcα/μR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock (2013)
  • Author(s): Honda S, Satoh K, Matsuoka Y, Matsushita T, Fujimoto M, Shibuya A
  • Organizer: 15th International Congress of Immunology. Mico Milano Congressi
  • Place of Presentation: Milan, Italy
  • Year and Date: 2013-08-23
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakahashi-Oda C, Tahara-Hanaoka S, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A
  • Organizer: 第41回日本免疫学会国際シンポジウム
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-06
• [Presentation] Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351) (2012)
  • Author(s): Sato K, Usui K, Honda S, Yoshizawa Y, Shibuya A
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-12-05
• [Presentation] MAIR-II(CD300d) on Ly-6C high inflammatory monocytes plays a crucial role in inflammatory responses in a murine sepsis model (2011)
  • Author(s): 戸塚直也, 田原聡子, 永井恵, 小田(中橋)ちぐさ, 人見香織, 栗田尚樹, 本多伸一郎, 渋谷和子, 渋谷彰
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] ナイーブマウス脾臓からの FDC の単離 (2011)
  • Author(s): 臼井健太, 本多伸一郎, 吉澤勇一, 田原聡子, 渋谷和子, 渋谷彰
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Iga/IgM受容体, Fcα/μ 受容体の二量体形成の解析 (2011)
  • Author(s): 高垣香菜, 本多伸一郎, 臼井健太, 吉澤勇一, 渋谷和子, 田原聡子, 渋谷彰
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] The role of CD155, a novel co-stimulatory molecule in CD4+ T cell, in contact dermatitis (2011)
  • Author(s): 山下由美, Wang Yhan , 吉岡文, 鍋倉宰, 田原聡子, 本多伸一郎, 渋谷彰, 渋谷和子
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-27
• [Presentation] 濾胞状樹状細胞上の IgA 受容体を介した粘膜免疫応答制御機構の解析 (2011)
  • Author(s): 本多伸一郎
  • Organizer: 平成 23年度第1回班会議
  • Place of Presentation: 京都大学医学部芝蘭会館(京都)
  • Year and Date: 2011-07-19
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/simple-search?query=%E6%9C%AC%E5%A4%9A+%E4%BC%B8%E4%B8%80%E9%83%8E
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001684