2013 Fiscal Year Final Research Report
Physiological and pathological roles of PYND, an anti-inflammatory NLR protein
| Project/Area Number |
23390092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SUDA Takashi 金沢大学, がん進展制御研究所, 教授 (70250090)
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| Co-Investigator(Renkei-kenkyūsha) |
OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610)
IMAMURA Ryu 金沢大学, がん進展制御研究所, 助教 (10311680)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | PYNOD / 自然免疫応答 / 獲得免疫応答 / 樹状細胞 / エフェクターT細胞 / 炎症性発がんモデル |
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| Research Abstract |
In this study, we have investigated the physiological role of PYNOD (a cytoplasmic protein belonging to the NLR family), especially its role in the immune system using PYNOD-deficient mice. PYNOD-deficient mice exhibited a clear defect in the delayed type hypersensitivity that is a type of acquired immune responses, whereas we could find no apparent defect in innate immune responses in these mice. However, draining lymph node cells isolated from PYNOD-deficient mice that had been immunized through skin routes exhibited normal antigen-specific IFN-gamma production, suggesting that peripheral antigen was successfully delivered to draining lymph nodes and effecter T cells were normally generated in these mice. Thus, it is likely that the cause of the defect in the acquired immune system of PYNOD-deficient mice exist in a process of or after the migration of effecter T cells from draining lymph nodes to peripheral tissues.
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Research Products
(15 results)
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[Journal Article] Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages2013
Author(s)
Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S., and Suda, T
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Journal Title
Int. Immunol
Volume: 25
Pages: 363-372
DOI
Peer Reviewed
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[Journal Article] Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells2012
Author(s)
Harashima, N., Inao, T., Imamura, R., Okano, S., Suda, T., and Harada, M
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Journal Title
Cancer Immunol. Immunother
Volume: 61
Pages: 667-676
DOI
Peer Reviewed
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[Journal Article] Fas Ligand Has a Greater impact than TNF- on Apoptosis and Inflammation in Ischemic Acute Kidney Injury2012
Author(s)
Furuichi, K., Kokubo, S., Hara, A., Imamura, R., Wang, Q., Kitajima, S., Toyama, T., Okumura, T., Matsushima, K., Suda, T., Mukaida, N., Kaneko, S. and Wada, T
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Journal Title
Nephron Extra
Volume: 2
Pages: 27-38
DOI
Peer Reviewed
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[Journal Article] Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity2011
Author(s)
Motani, K., Kushiyama, H., Imamura, R., Kinoshita, T., Nishiuchi, T., and Suda, T
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 33963-33972
DOI
Peer Reviewed
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