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2013 Fiscal Year Final Research Report

Molecular Basis of differentiation of Entamoeba histolytica

Research Project

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Project/Area Number 23390099
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

NOZAKI Tomoyoshi  国立感染症研究所, 寄生動物部, 部長 (60198588)

Co-Investigator(Kenkyū-buntansha) TSUKUI Kumiko   (00420092)
SATO Dan   (50468477)
Co-Investigator(Renkei-kenkyūsha) JEELANI Ghulam   (80725820)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords感染症 / 分化 / トランスクリプトーム / 寄生虫 / 病原性
Research Abstract

Metabolomics and transcriptomics analyses of encystation in Entamoeba invadens was conducted. We demonstrated a comprehensive view of metabolisms during encystation, including several unpredicted pathways and metabolites. These data should help us to further identify key regulatory points of gene expression and metabolic fluxes, and eventually understand elaborate regulation of entire metabolic network during encystation.

  • Research Products

    (24 results)

All 2014 2013 2012 2011

All Journal Article (13 results) Presentation (11 results) (of which Invited: 1 results)

  • [Journal Article] Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa2014

    • Author(s)
      Makiuchi, T. and Nozaki, T
    • Journal Title

      Biochimie

      Volume: 100 Pages: 3-17

  • [Journal Article] Ligand heterogeneity of the cysteine protease binding protein family in the parasitic protist Entamoeba histolytica2014

    • Author(s)
      Marumo, K., Nakada-Tsukui, K., Tomii, K., and Nozaki, T
    • Journal Title

      Int. J. Parasitol

      Volume: (in press)

  • [Journal Article] Metabolomic analysis of Entamoeba : applications and implications2014

    • Author(s)
      Jeelani, G. and Nozaki, T
    • Journal Title

      Curr. Opin. Microbiol

      Volume: (in press)

  • [Journal Article] Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan Entamoeba histolytica2013

    • Author(s)
      Furukawa, A., Nakada-Tsukui, K., and Nozaki, T
    • Journal Title

      Inf. Immun

      Volume: 81 Pages: 1820-1829

  • [Journal Article] Iron sulfur clusters, their biosythesis and biological functions in protozoan parasites2013

    • Author(s)
      Ali, V. and Nozaki, T
    • Journal Title

      Adv. Parasiol

      Volume: 83 Pages: 1-92

  • [Journal Article] Transcriptome analysis of encystation in Entamoeba invadens2013

    • Author(s)
      Escueta- De Cadiz, A., Jeelani, G., Nakada-Tsukui, K., Caler, E., and Nozaki, T
    • Journal Title

      PLoS One

      Volume: 8 Pages: e74840

  • [Journal Article] Differential gene expression in Giardia lamblia under oxidative stress : Significance in eukaryotic evolution2013

    • Author(s)
      Raj, D., Ghosh, E., Mukherjee, A.K., Nozaki, T., and Ganguly, S
    • Journal Title

      Gene

      Volume: (doi:pii:S0378-1119(13)01574-6)

  • [Journal Article] Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica2012

    • Author(s)
      Penuliar, G. M., Furukawa, A., Nakada-Tsukui, K., Husain, A., Sato, D., and Nozaki, T
    • Journal Title

      J. Antimicrob. Chemother

      Volume: 67 Pages: 375-386

  • [Journal Article] Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica2012

    • Author(s)
      Furukawa, A., Nakada-Tsukui, K., and Nozaki, T
    • Journal Title

      PLoS Pathog

      Volume: (doi:/journal.ppat.1002539)

  • [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica2011

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., and Nozaki, T
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 275

  • [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica2011

    • Author(s)
      Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., and Nozaki, T
    • Journal Title

      PLoS Negl. Trop. Dis

      Volume: 5 Pages: e1263

  • [Journal Article] Amebiasis in HIV-1-infected Japanese men : clinical features and response to therapy2011

    • Author(s)
      Watanabe, K., Gatanaga, H., de Cadiz, A.E., Tanuma, J., Nozaki, T., Oka, S
    • Journal Title

      PLoS Negl. Trop. Dis

      Volume: 5 Pages: e1318

  • [Journal Article] Mechanism of trifluoromethionine resistance in Entamoeba histolytica2011

    • Author(s)
      Penuliar, G. M., Furukawa, A., Sato, D., and Nozaki, T
    • Journal Title

      J. Antimicrob. Chemother

      Volume: 66 Pages: 2045-2052

  • [Presentation] Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica2013

    • Author(s)
      Jeelani, G., Husain, A., Sato, D., Soga, T., Suematsu, M., Nozaki, T
    • Year and Date
      20130000
  • [Presentation] Metabolome of encystation in Entamoeba histolytica2012

    • Author(s)
      Jeelani, G., Dan, S., Husain, A., Escueta-de Cadiz, Sugimoto, M., Soga, T., Suematsu, M., and Nozaki, T
    • Organizer
      Metabolomics of Protozoan parasites
    • Place of Presentation
      Glasgow, U.K.
    • Year and Date
      20120910-14
  • [Presentation] Organelle metabolomics of Entamoeba histolytica2012

    • Author(s)
      Chiba, Y., Dan, S., Makiuchi, T., Jeelani, G., Soga, T., and Nozaki, T
    • Organizer
      Metabolomics of Protozoan Parasites
    • Place of Presentation
      Glasgow, U.K.
    • Year and Date
      20120910-14
  • [Presentation] 赤痢アメーバが L- システイン欠乏下で特異的に賛成するアミノ酸とリン脂質の同定, 及びその生合成経路の解明2012

    • Author(s)
      佐藤暖 , Afzal Husain, Ghulam Jeelani, 曽我朋義 , 野崎智義
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      Nishinomiya, Hyogo
    • Year and Date
      20120323-24
  • [Presentation] Entamoeba invadens における安定発現株の樹立2012

    • Author(s)
      間瀬望, 津久井久美子, 野崎智義
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      Nishinomiya, Hyogo
    • Year and Date
      20120323-24
  • [Presentation] Metabolic profiling of the protozoan parasite Entamoeba revealed activation of unpredicted pathway during encystation2012

    • Author(s)
      Jeelani, G, , Sato, S., Husain, A., Escueta-de Cadiza, A., Sugimoto, M., Soga, T., Suematsu, M., and Nozaki, T
    • Year and Date
      20120000
  • [Presentation] Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica2012

    • Author(s)
      Husain, A., Sato, D., Jeelani, G., Soga, T., and Nozaki, T
    • Year and Date
      20120000
  • [Presentation] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica2011

    • Author(s)
      Nozaki, T
    • Organizer
      Joint International Tropical Medicine Meeting
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20111201-02
  • [Presentation] Function and transport of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica2011

    • Author(s)
      Nozaki, T
    • Organizer
      The 1st Asian Conference of Prosistology
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20111003-06
  • [Presentation] A novel import machinery of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica2011

    • Author(s)
      Nozaki, T
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      Sapporo, Japan. (Symposist and Convenor)
    • Year and Date
      20110908-10
  • [Presentation] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica2011

    • Author(s)
      Nozaki, T
    • Organizer
      The Second Cross-Straits and Asia Pacific International Conference on Parasites
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      20110831-0902
    • Invited

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Published: 2015-06-25  

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