2013 Fiscal Year Final Research Report
Host factors involved in natural HIV resistance
| Project/Area Number |
23390111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIODA Tatsuo 大阪大学, 微生物病研究所, 教授 (00187329)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | HIV感染症 / 宿主因子 / 感染抵抗性 / 生理的リガンド |
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| Research Abstract |
In order to identify novel therapeutic target(s) for AIDS/HIV-infection, we have analyzed detailed molecular mechanisms of anti-viral activity of HIV restriction factor TRIM5alpha. We were able to obtain following results: 1.In situ uncoating assay revealed that an HIV-1 mutant strain, which could replicate in the presence of monkey TRIM5alpha, showed delayed uncoating process. 2. A naturally occurring single amino acid substitution in human TRIM5alpha linker region between coiled-coil and SPRY regions affects its anti-HIV-1 activity. 3. TRIM5alpha could bind to TAB2, which is in the TLR4-mediated signal transduction pathway, probably through its SPRY region.
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Research Products
(39 results)
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[Journal Article] Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors2013
Author(s)
Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, Fujiwara S, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A
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Journal Title
J Virol
Volume: 87(21)
Pages: 11447-11461
DOI
Peer Reviewed
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[Journal Article] TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 12013
Author(s)
Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama E, Akari H
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Journal Title
J Gen Virol
Volume: 94(Pt 6)
Pages: 1318-24
DOI
Peer Reviewed
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[Journal Article] Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells2013
Author(s)
Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi A
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Journal Title
Microbes and Infection
Volume: 15(1)
Pages: 56-65
DOI
Peer Reviewed
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[Journal Article] Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients2013
Author(s)
Likanonsakul S, Rattanatham T, Feangvad S, Uttayamakul S, Prasithsirikul W, Srisopha S, Nitiyanontakij R, Tengtrakulcharoen P, Tarkowski M, Riva A, Nakayama EE, Shioda T
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Journal Title
AIDS Res Hum Retroviruses
Volume: 29(1)
Pages: 142-50
DOI
Peer Reviewed
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[Journal Article] Elicitation of Both Anti HIV-1 Env Humoral and Cellular Immunities by Replicating Vaccinia Prime Sendai Virus Boost Regimen and Boosting by CD40Lm2012
Author(s)
Zhang X, Sobue T, Isshiki M, Makino S, Inoue M, Kato K, Shioda T, Ohashi T, Sato H, Komano J, Hanabusa H, Shida H
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Journal Title
PLoS One
Volume: 7(12)
Pages: e51633
DOI
Peer Reviewed
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[Journal Article] The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5 α2012
Author(s)
Miyamoto T, Nakayama EE, Yokoyama M, Ibe S, Takehara S, Kono K, Yokomaku Y, Pizzato M, Luban J, Sugiura W, Sato H, Shioda T
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Journal Title
PLoS One
Volume: 7(10)
Pages: e47757
DOI
Peer Reviewed
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[Presentation] 抗レトロウイルス療法副作用の発症に関わる宿主因子2011
Author(s)
中山英美 , Likanonsakul, S., Rattanatham, T., Feangvad, S., Uttayamakul, S., Prasithsirikul, W., Tarkowski, M., Riva, A., 塩田達雄
Organizer
第25回エイズ学会学術集会・総会
Place of Presentation
東京
Year and Date
20111130-1202
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[Presentation] Genotypic variation of cynomolgus monkey TRIM5Alpha determines the susceptibility to monkey-tropic HIV-1 infection2011
Author(s)
Saito, A., Nomaguchi, M., Kono, K., Nakayama, EE., Shioda T., Yoshida1, T., Yasutomi, Y., Matano, T., Adachi, A., Akari, H
Organizer
第59回日本ウイルス学会学術集会 (International Congress of Virology)
Place of Presentation
札幌
Year and Date
20110911-16
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[Presentation] A single amino acid of human immunodeficiency virus type 2 capsid protein affects conformation of two external loops and viral sensitivity to TRIM5α2011
Author(s)
Miyamoto, T., Yokoyama, M., Kono, K., Shioda T., Sato, H., Nakayama, EE
Organizer
第59回日本ウイルス学会学術集会(International Congress of Virology)
Place of Presentation
札幌
Year and Date
20110911-16
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[Presentation] Simian-Tropic HIV-1 NL-4/5S6/7SVIFS shows slower capsid uncoating in human Cells2011
Author(s)
Kono, K., Kuroishi, A., Nakayama, EE., Hulme, AE., Hope, TJ., Shioda T
Organizer
第59回日本ウイルス学会学術集会(International Congress of Virology)
Place of Presentation
札幌
Year and Date
20110911-16
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