Mechanism of herpesvirus infection

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390112
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: Osaka University
• Principal Investigator: ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
• Co-Investigator(Kenkyū-buntansha): SUENAGA Tadahiro 大阪大学, 微生物病研究所, 助教 (20396675) ; UEHORI Junji 大阪大学, 微生物病研究所, 助教 (20432429)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 膜融合 / ヘルペスウイルス / 糖鎖 / エントリー

Outline of Final Research Achievements

We have analyzed association of herpesvirus glycoprotein B (gB) with PILR and found that PILR recognizes both glycan and peptide structure of gB (Kuroki et al. PNAS 2014). From the analyses of varicella zoster virus (VZV) gB and MAG, we found that specific glycan structures on gB is involved in membrane fusion at VZV infection. On the other hand, we have established new method to modify the genome of herpesviruses using CRISPR-Cas9 system (Suenaga et al., Microbes Immunol. 2014). We have also established membrane fusion assay of human herpesivirus 6 (HHV6) and found that gB, gH, gL and gQ are required for membrane fusion of HHV6 (Tanaka et al., J. Virol. 2013).

Free Research Field

医歯薬学