2013 Fiscal Year Final Research Report
Analysis of poliovirus permeation mechanism through blood brain barier
| Project/Area Number |
23390113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
NOMOTO Akio 公益財団法人微生物化学研究会, 微生物化学研究所, 所長 (70112670)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKAWA Masayuki (公財)微生物化学研究会, 微生物化学研究所, 研究員 (90398868)
YAMASAKI Manabu (公財)微生物化学研究会, 微生物化学研究所, 研究員 (50442570)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ポリオウイルス / 病原性 / 血液脳関門 / 特異的体内伝播 / 宿主因子 |
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| Research Abstract |
Poliovirus dissemination routes were investigated by using mouse capillary endothelial cells and mouse in vitro BBB model. Main interests were i) PV permeation mechanism through blood brain barrier (BBB), and ii) development of drug delivery system through BBB. Our data confirm that PV utilizes transferrin receptor to invade the central nervous system, and suggest that other host molecule might be involved as additional receptors in the BBB permeation. In addition, our data indicates peptide regions on transferrin receptor and PV particle involved in the binding.
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[Journal Article] Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses2013
Author(s)
Wendell Smith, Peter Tomasec, Rebecca Aicheler, Andrea Loewendorf, Ivana Nemcovicova, Eddie C.Y. Wang, Richard J. Stanton, Matt Macauley, Paula Norris, Laure Willen, Eva Ruckova, Akio Nomoto, Pascal Schneider, Gabriele Hahn, Dirk M. Zajonc, Carl F. Ware, Gavin W.G. Wilkinson & Chris A. Benedict
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Journal Title
Cell Host & Microbe
Volume: 13
Pages: 324-335
DOI
Peer Reviewed
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[Journal Article] HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells2012
Author(s)
Naoko Kubota, Yasutaka Inayoshi, Naoko Satoh, Takashi Fukuda, Kenta Iwai, Hiroshi Tomoda, Michinori Kohara, Kazuhiro Kataoka, Akira Shimamoto, Yasuhiro Furuichi, Akio Nomoto, Akira Naganuma & Shusuke Kuge
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Journal Title
FEBS Lett
Volume: 586
Pages: 2318-2325
DOI
Peer Reviewed
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