2013 Fiscal Year Final Research Report
Cellular immune responses in AIDS virus controllers
| Project/Area Number |
23390115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MATANO TETSURO 国立感染症研究所, エイズ研究センター, センター長 (00270653)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ウイルス / 感染症 / 微生物 / 免疫学 / エイズ / 細胞傷害性Tリンパ球 / 変異 |
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| Research Abstract |
To elucidate the mechanism for sustained control of HIV replication, this study analyzed vaccinated rhesus macaques that controlled simian immunodeficiency virus (SIV) replication for more than 2 years after challenge. Remarkably, half of these SIV controllers had multiple proviral gag and nef mutations at 2 years whereas the remaining half did not. At 1 year, the former group showed broader cytotoxic T lymphocyte (CTL) responses targeting viral non-Gag/Nef proteins as well as Gag/Nef, whereas Gag- and Nef-specific CTL responses were still dominant in the latter. The latter group represents an extremely stable SIV control by Gag/Nef-specific CTLs, providing a possible mechanism of functional HIV cure by CTLs.
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[Journal Article] Tertiary mutations stabilize CD8^+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus2014
Author(s)
Burwitz BJ, Wu HL, Reed JS, Hammond KB, Newman LP, Bimber BN, Nimiyongskul FA, Leon EJ, Maness NJ, Friedrich TC, Yokoyama M, Sato H, Matano T, O'Connor DH, Sacha JB
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Journal Title
J Virol
Volume: 88
Pages: 3598-3604
Peer Reviewed
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[Journal Article] A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques2013
Author(s)
Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T
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Journal Title
PLoS ONE
Volume: 8
Pages: e54300
Peer Reviewed
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[Journal Article] Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques2012
Author(s)
Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T
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Journal Title
J Virol
Volume: 86
Pages: 738-745
Peer Reviewed
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[Journal Article] Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques2012
Author(s)
Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T
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Journal Title
J Virol
Volume: 86
Pages: 6481-6490
Peer Reviewed
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[Journal Article] Immunogenicity of repeated Sendai viral vector vaccination in macaques2012
Author(s)
Kurihara K, Takahara Y, Nomura T, Ishii H, Iwamoto N, Takahashi N, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Moriya C, Matano T
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Journal Title
Microbes Infect
Volume: 14
Pages: 1169-1176
Peer Reviewed
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[Journal Article] Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge2011
Author(s)
Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T
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Journal Title
Biochem Biophys Res Commun
Volume: 408
Pages: 615-619
Peer Reviewed
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[Journal Article] Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques2011
Author(s)
Nakamura M, Takahara Y, Ishii H, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T, Matsuoka S
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Journal Title
Microbiol Immunol
Volume: 55
Pages: 768-773
Peer Reviewed
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[Journal Article] Intranasal Sendai viral vector vaccination is more immunogenic than intramuscular under pre-existing anti-vector antibodies2011
Author(s)
Moriya C, Horiba S, Kurihara K, Kamada T, Takahara Y, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Matano T
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Journal Title
Vaccine
Volume: 29
Pages: 8557-8563
Peer Reviewed
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[Presentation] Impact of therapeutic vaccination on CTL immunodominance and viral suppression in SIV-infected rhesus macaques under HAART2012
Author(s)
Takahara Y, Nakamura M, Matsuoka S, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse T, Kimura A, Matano T
Organizer
Towards an HIV cure, Pre-conference symposium and The XIXth International AIDS Conference
Place of Presentation
Washington, DC, USA
Year and Date
20120721-26
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[Presentation] Efficacy of single epitope-specific cytotoxic T lymphocyte induction by vaccination against a simian immunodeficiency virus challenge2011
Author(s)
Ishii H, Iwamoto N, Matsuoka S, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse T, Kimura A, Matano T
Organizer
The XVth International Congress of Virology
Place of Presentation
Sapporo
Year and Date
2011-09-16
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