2013 Fiscal Year Final Research Report
Molecular basis for Epstein-Barr virus replication
| Project/Area Number |
23390118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TSURUMI Tatsuya 愛知県がんセンター(研究所), 腫瘍ウイルス学部, 部長 (90172072)
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| Co-Investigator(Renkei-kenkyūsha) |
KANDA Teru 愛知県がんセンター(研究所), 腫瘍ウイルス学部, 室長 (50333472)
MURATA Takayuki 愛知県がんセンター(研究所), 腫瘍ウイルス学部, 研究員 (30470165)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | EBウイルス / 複製 / 転写 / 増殖 |
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| Research Abstract |
Epstein-Barr virus possesses two alternative life cycles, latent and lytic.
In the latent phase, reactivation of BZLF1 promoter is inhibited. We determined that histons around the promoter region we re negatively methylated and positive histon markers were increased after induction of lytic replication. JDP2 transcription factor contributed the establishment of the latent infection. In the lytic phase, viral replication occurs in replication compartments(RC). BMRF-1 core exists within RC. Viral DNA packaging proteins were found in the core and viral immediate-eartly and early transcription occurs outside the core, while late transcription was inside. Thus, each events were compartmentalized by the BMRF-1 core.
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[Journal Article] Role of down-regulated neutral ceram idase during all-trans retinoic acid induced neuronal differentiation in SH-SY5Y neuroblastom a cells2012
Author(s)
Tanaka K, Tam iya-Koizum i K, Hagiwara K, Ito H, Takagi A, Kojim a T, Suzuki M, Iwaki S, Fujii S, Nakamura M, Banno Y, Kannagi R, Tsurumi T, Kyogashima M, Murate T
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Journal Title
J Biochem
Volume: 151
Pages: 611-620
Peer Reviewed
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