2013 Fiscal Year Final Research Report
Clarification of molecular mechanisms for regulating dendritic cell subset functions
| Project/Area Number |
23390124
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
KAISHO Tsuneyasu 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門教授 (60224325)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 樹状細胞 / インターフェロン / クロスプライミング / シグナル伝達 |
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| Research Abstract |
Dendritic cells (DCs) consist of various subsets and functions in a subset-specific manner. Plasmacytoid DC (PDC) produce type I interferons (IFNs) in response to the signaling through nucleic acid sensors, TLR7/9, thereby being involved in antiviral defense and pathogenesis of certain autoimmune diseases. An Ets family transcription factor, Spi-B, highly expressed in PDC, is critical for this PDC activity. Furthremore, CD8alpha+ DC is featured by its high crosspresenting ability. The mutant mice, in which CD8alpha+ DC can be traced by fluorescence protein expression and ablated conditionally, were generated. By using the mice, CD8alpha+ DC was found to be critical for in vivio crosspresentation. Thus, molecular and cellular mechansims on the DC subset-specific functions were clarified.
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Research Products
(51 results)
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[Journal Article] Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria2014
Author(s)
H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
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Journal Title
Cell Host Microbe
Volume: 15
Pages: 551-563
DOI
Peer Reviewed
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[Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells2013
Author(s)
T. Kawashima, A. Kosaka, H. Yan, G. Zijin, R. Uchiyama, R. Fukui, D. Kaneko; Y. Kumagai; D.-J. You, J. Carreras, S. Uematsu, M. H. Jang, O. Takeuchi, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito, I. Nishimura, N. M. Tsuji
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Journal Title
Immunity
Volume: 38
Pages: 1187-1197
DOI
Peer Reviewed
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[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013
Author(s)
C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
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Journal Title
J. Immunol
Volume: 190
Pages: 6071-6082
DOI
Peer Reviewed
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[Journal Article] Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein2012
Author(s)
H. Hemmi, N. Zaidi, B. Wang, I. Matos, C. Fiorese, A. Lubkin, L. Zbytnuik, K. Suda, K. Zhang, M. Noda, T. Kaisho, R. M. Steinman, J. Idoyaga
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Journal Title
J. Immunol
Volume: 188
Pages: 1147-1155
DOI
Peer Reviewed
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[Journal Article] The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells2012
Author(s)
T. Kanaya, K. Hase, D. Takahashi, S. Fukuda, K. Hoshino, I. Sasaki, H. Hemmi, K.A. Knoop, N. Kumar, M. Sato, T. Katsuno, O. Yokosuka, K. Toyooka, K. Nakai, A. Sakamoto, Y. Kitahara, T. Jinnohara, S.J. McSorley, T. Kaisho, I.R. Williams, H. Ohno
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Journal Title
Nat Immunol
Volume: 13(8)
Pages: 729-36
DOI
Peer Reviewed
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[Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012
Author(s)
I. Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
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Journal Title
Blood
Volume: 120
Pages: 4733-4743
DOI
Peer Reviewed
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[Journal Article] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo2011
Author(s)
H. Takagi, T. Fukaya, K. Eizumi, Y. Sato, K. Sato, A. Shibazaki, H. Otsuka, A. Hijikata, T. Watanabe, O. Ohara, T. Kaisho, B. Malissen, K. Sato
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Journal Title
Immunity
Volume: 35
Pages: 958-971
DOI
Peer Reviewed
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[Presentation] Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective IFN- β2013
Author(s)
T. Kawashima, H Yan, Z. Guo, J. Carreras, R. Uchiyama, R. Fukui, T. Kaisho , S. Akira, K. Miyake, H. Tsutsui, T. Saito, N.M.Tsuji
Organizer
第42回日本免疫学会総会
Place of Presentation
幕張メッセ
Year and Date
20131211-13
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[Presentation] 形質細胞様樹状細胞による炎症反応とT細胞免疫応答の制御2011
Author(s)
H. Takagi, T. Fukaya, Y. Sato, K. Sato, A. Shibazaki, A. Hijikata, O. Ohara, T. Kasiho , B. Malissen, K. Sato
Organizer
第40回日本免疫学会総会
Place of Presentation
幕張メッセ
Year and Date
20111127-29
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[Presentation] Siglec-H による形質細胞様樹状細胞の機能制御2011
Author(s)
K. Sato, H. Takagi, T. Fukaya, Y. Sato, K. Sato, A. Shibazaki, A. Hijikata, O. Ohara, T. Kasiho , B. Malissen
Organizer
第40回日本免疫学会総会
Place of Presentation
幕張メッセ
Year and Date
20111127-29
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[Presentation] TLR3を介した乳酸菌2本鎖RNA の IFN-β産生誘導/Double-stranded RNA of lactic acid bacteria triggers TLR3 -mediated IFN-ɤ production by dendritic cells2011
Author(s)
T. Kawashima, H. Yan, Z. Guo, R. Uchiyama, J. Carreras, T. Kaisho , O. Takeuchi, S. Akira, H. Tsutsui, T. Saito, I. Nishimura, N. Tsuji
Organizer
第40回日本免疫学会総会
Place of Presentation
幕張メッセ幕張メッセ
Year and Date
20111127-29
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