2013 Fiscal Year Final Research Report
The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment
| Project/Area Number |
23390142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMA Yu 熊本大学, 薬学部, 助教 (00457590)
WATANABE Hiroshi 熊本大学, 薬学部, 准教授 (70398220)
OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | DDS / アルブミン / 一酸化窒素 / 癌治療 |
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| Research Abstract |
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues, served as a basis for development of macromolecular anticancer therapy. Although many factors that affect vascular permeability in tumors have been identified, some parts of tumors do not exhibit the EPR effect and show less accumulation of macromolecules than other parts. We previously developed S-nitrosated HSA-Dimer (SNO-HSA-Dimer) as an enhancer of the EPR effect by applying nitric oxide (NO)-releasing agents in tumors selectively. In this study, we performed the effect of SNO-HSA-Dimer on the anti-tumor effect of two macromolecular anti-tumor drugs in C26 tumor-bearing mice. Intriguingly, SNO-HSA-Dimer inhibited the side effects of Doxil; through augmenting the EPR effect.
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[Journal Article] Tuning of Poly-S-Nitrosated Human Serum Albumin as Superior Antitumor Nanomedicine2014
Author(s)
Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T
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Journal Title
DOI
Peer Reviewed
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[Journal Article] S-guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, Otagiri M
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Journal Title
J Pharm Sci
Volume: 101(9)
Pages: 3222-9
DOI
Peer Reviewed
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