2013 Fiscal Year Final Research Report
Development of targeted medical care (simultaneous diagnostic imaging and therapy) for pathogenic angiogenesis using fibrinolytic metabolites
| Project/Area Number |
23390151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MATSUURA Eiji 岡山大学, 医歯(薬)学総合研究科, 教授 (20181688)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 血管新生 / ベータ2-グリコプロテインI / 抗血管新生剤 / B2GPI-ドメインI / nicked B2GPI / PETイメージング / 質量分析 / DDSキャリア |
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| Research Abstract |
By the cytostatic activity test and angiogenesis imaging analysis with human umbilical vein endothelial cells, we confirmed that DI of beta2-glycoprotein I (B2GPI) revealed dose- and time-dependent cytostatic and anti-angiogenesis activity. 64Cu-labeled DI and 64Cu-labeled B2GPI were prepared and used for PET/CT imaging of tumor-bearing mice. DI showed high tumor/blood ratio. 64Cu-labeled and B2GPI-bound liposomes were prepared as an experimental model of the Theranostics (simultaneous diagnostic imaging and therapy) technology.
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