2013 Fiscal Year Final Research Report
Central modulation of spinal nociceptive synaptic transmission in vivo
| Project/Area Number |
23390156
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
FURUE Hidemasa 生理学研究所, 生体情報研究系, 准教授 (20304884)
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| Co-Investigator(Kenkyū-buntansha) |
JINNO Shozo 九州大学, 医学研究院, 教授 (10325524)
FUKAZAWA Yugo 名古屋大学, 医学研究科, 准教授 (60343745)
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| Co-Investigator(Renkei-kenkyūsha) |
IMOTO Keiji 生理学研究所, 所長 (00176512)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 疼痛の神経機構 / 鎮痛 / 下行性痛覚抑制 / 光操作 / 神経生理 / ノルアドレナリン / 鎮静 / in vivoパッチクランプ |
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| Research Abstract |
Descending noxious inhibitory system was studied with a combination of in vivo optogenetic and electrophysiological approaches. Locus coeruleus neurons in the brain stem in vivo elicited a slow inward current without eliciting a barrage of synaptic responses in response to noxious cutaneous stimulation, and showed an excitation-inhibition, biphasic firing response. A tonic activation of the locus coeruleus neurons expressing channel rhodopsin by light stimulation excited spinal GABAergic neurons to suppress noxious synaptic transmission. Alpha2 agonist, a chronically used sedative agent, at low doses also activated the descending pontospinal noradrenergic system. The present study represents a new target for the treatment of chronic pain.
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