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2013 Fiscal Year Final Research Report

Elucidating the epigenetic effects of environmental chemicals and their impacts on next generation

Research Project

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Project/Area Number 23390157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionHokkaido University

Principal Investigator

KAORU Azumi  北海道大学, 環境健康科学研究教育センター, 客員研究員 (90221720)

Co-Investigator(Kenkyū-buntansha) KISHI Reiko  北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
Co-Investigator(Renkei-kenkyūsha) SASAKI Seiko  北海道大学, 大学院・医学研究, 助教 (30448831)
IWANO Hidetomo  酪農学園大学, 獣医学部, 准教授 (60382488)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords環境化学物質 / 環境疫学 / 前向きコホート / エピジェネティクス / DNAメチル化
Research Abstract

We investigated the effects of prenatal exposure to environmental chemicals on IGF2/H19 and LINE1 methylation. Among 514 pregnant women recruited at Toho Hospital (Sapporo, Japan) during 2002-2005, 267 mother-infant pairs with cord blood samples were subjected to this study. DNA methylation was quantified by bisulfite pyrosequence. Concentrations of PFOS, PFOA, MEHP, Dioxins, PCBs in maternal blood and methylmercury in maternal hair were analyzed into their association with DNA methylation in multiple linear regression models. After adjustment for potential confounders, we observed hypomethylation at IGF2 by PFOA exposure (beta = -1.60, 95% CI: -2.98 to -0.22), hypomethylation at H19 by MEHP exposure (beta = -0.84, 95% CI: -1.68 to -0.00) and hypermethylation at LINE1 by methylmercury exposure (beta = 0.71, 95% CI: 0.07 to 1.36).

  • Research Products

    (4 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile-updated 20132013

    • Author(s)
      Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, et al
    • Journal Title

      Environmental health and preventive medicine

      Volume: 18(6) Pages: 429-450

    • Peer Reviewed
  • [Journal Article] 環境化学物質曝露の次世代影響の解明におけるエピジェネティクス研究2012

    • Author(s)
      安住薫, 小林祥子, 岸玲子
    • Journal Title

      北海道公衆衛生学雑誌

      Volume: 26(2) Pages: 29-38

    • Peer Reviewed
  • [Presentation] 環境化学物資の胎児期曝露が臍帯血IGF2DNA メチル化に及ぼす影響2013

    • Author(s)
      小林祥子, 安住薫, 宮下ちひろ, 小林澄貴, 佐々木成子, 石塚真由美, 岸玲子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      20130324-26
  • [Remarks]

    • URL

      http://www.cehs.hokudai.ac.jp

URL: 

Published: 2015-06-25  

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