2013 Fiscal Year Final Research Report
Nested case-control study on the effects of prenatal exposure to PCBs
| Project/Area Number |
23390158
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAI Kunihiko 東北大学, 医学(系)研究科(研究院), 教授 (00291336)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUTA Nozomi 東北大学, 大学院・医学系研究科, 助教 (40547709)
KUROKAWA Naoyuki 宮城教育大学, 教育学部, 講師 (30431505)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | コホート内症例対照研究 / ポリ塩化ビフェニル / 胎児期ばく露 / 神経行動学 / 出生コホート調査 / 知能検査 |
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| Research Abstract |
Environmental exposures to polychlorinated biphenyls (PCBs) have been suggested as a risk factor for neurobehavioral development in children. A nested case-control study was performed to investigate the association between the cognitive outcome at 42 months and the prenatal exposures to PCB and DDE. The Tohoku Study of Child Development cohort contains cord blood samples collected at the delivery of healthy pregnant women of the Tohoku district of east Japan. The cognitive score was assessed with the Kaufman Assessment Battery for Children (K-ABC). After adjusting with maternal IQ, maternal age, gestational days, maternal fish intake, plasma omega-3/omega-6 polyunsaturated fatty acids, and others, no statistically significant association with the cognitive and simultaneous processing scores was seen for any PCB and DDE.
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