2013 Fiscal Year Final Research Report
Chemical and biological diversity of arsenic compounds derived from marine products: Elucidation of their pharmacokinetics and metabolic activation
| Project/Area Number |
23390165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka City University |
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Principal Investigator |
ENDO Ginji 大阪市立大学, 医学(系)研究科(研究院), 教授 (20160393)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANAKA Kenzo 日本大学, 薬学部, 教授 (50182572)
YAMANO Yuko 昭和大学, 医学部, 准教授 (30167580)
TACHIKAWA Mariko 日本大学, 薬学部, 教授 (90139098)
HATA Akihisa 千葉科学大学, 危機管理学部, 助教 (10433690)
FUJITANI Noboru 千葉科学大学, 危機管理学部, 教授 (10156888)
TAKEUCHI Akito 大阪市立大学, 大学院・医学研究科, 研究員 (20631360)
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| Co-Investigator(Renkei-kenkyūsha) |
ENDO Yoko 独立行政法人, 労働者健康福祉機構・関西労災病院, 産業中毒研究センター長 (50193438)
YAMAUCHI Takenori 宮崎大学, 医学部, 助教 (40576287)
SHIMODA Yasuyo 日本大学, 薬学部, 大学院生
KUROSAWA Hidetoshi 日本大学, 薬学部, 客員研究員
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 食品 / 食の安全 / リスク評価 / ヒ素 / 海産物 |
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| Research Abstract |
From the results of arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh, the best biomarker of inorganic arsenics (iAs) exposure is urinary iAs and monomethylarsonic acid (MMA(V)) concentration. To evaluate the risk of dietary arsenic, we conducted wakame seaweed ingestion experiment. The detected urinary arsenic species were dimethylarsinic acid (DMA(V)), oxo-dimethylarsinoylethanol, oxo-dimethylarsinoylacetate, and some unidentified species. We developed and validated a GC-MS method to determine arsenic in urine.
Analytical examination using HPLC-TOF-MS equipped with ODS column and GC-FPD showed that an in vitro reaction between dimethylmonothioarsinic acid (DMMTA(V)) and GSH produced hydrogen sulfide via the generation of dimethylmonothioarsinic acid-GSH (DMMTA(V)-GSH) complex.
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[Presentation] Development of analytical method for biological monitoring of inorganic arsenic exposure using gas chromatography -mass spectrometry2013
Author(s)
Takeuchi A, Namera A, Kawasumi Y, Imanaka T, Sakui N, Ota H, Endo Y, Sumino K, Endo G
Organizer
Environment and Health -Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
Place of Presentation
Basel, Switzerland
Year and Date
20130819-23
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[Presentation] In vivo study of arsine exposure in hairless mice : percutaneous absorption vs. whole-body inhalation2013
Author(s)
Yamano Y, Nagano K, Yamanaka K, Hata A, Nakadate T, Endo Y, Endo G
Organizer
Environment and Health -Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
Place of Presentation
Basel, Switzerland
Year and Date
20130819-23
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[Presentation] Possible Production of arsenic adduct due to the exposure of mouse preserved blood to arsine in vitro2013
Author(s)
Yamauchi T, Yamano Y, Yamanaka K, Hata A, Kuroda Y, Endo Y, Endo G
Organizer
Environment and Health -Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
Place of Presentation
Basel, Switzerland
Year and Date
20130819-23
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[Presentation] Arsenic metabolites in human urine after ingestion of seafood2013
Author(s)
Hata A, Yamanaka K, Kurosawa H, Yamano Y, Endo Y, Fujitani N, Endo G
Organizer
Environment and Health -Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
Place of Presentation
Basel, Switzerland
Year and Date
20130819-23
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