The effect of soluble form LOX-1 and LOX-1 ligands containing apolipoprotein B on subclinical atherosclerosis in community dwellers..

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390178
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Keio University
• Principal Investigator: OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Yoshihiro 国立循環器病研究センター, 予防健診部, 部長 (10312224) ; MISHIWAKI Yuji 東邦大学, 医学部, 教授 (40237764) ; HIGASHIYAMA Aya 兵庫医科大学, 医学部, 助教 (20533003)
• Co-Investigator(Renkei-kenkyūsha): SAWAMURA Tatsuya 国立循環器病研究センター, 血管生理部, 部長 (30243033) ; MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452) ; UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
• Research Collaborator: AKIRA Sekikawa University of Pittsburgh, Associate Professor
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: ＡｐｏＢ含有LOX-1リガンド / 血中可溶型LOX-1 / 疫学調査 / carotid IMT / CAVI / 動脈硬化 / 生活習慣

Outline of Final Research Achievements

The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC) and usual measurement of oxidized LDL. The association between LAB and subclinical atherosclerosis, such as intima-media thickness (IMT) of carotid artery and Cardio Ankle Vascular Index, CAVI, was investigated in community dwellers. In group with a mean age of 45, serum LAB was associated with an increased carotid IMT in US Caucasian men independently of various risk factors (N= 297); however, there was no significant relationship between LAB and IMT in Japanese men (N= 310). In other Japanese group with a mean age of 64 (N= 992), serum LAB was associated with an increased carotid IMT only in men with hypercholesterolemia. In 515 healthy Japanese (310 men and 205 women) living in Kobe city, the plasma LAB showed a positive association with the CAVI in men but not in women. LAB may be a useful marker for detecting early stage of atherosclerosis in "healthy" individuals.

Free Research Field

公衆衛生学