2013 Fiscal Year Final Research Report
Role of mutated hepatic progenitor cells on hepatocarcinogenesis
| Project/Area Number |
23390196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
MARUSAWA HIROYUKI 京都大学, 医学(系)研究科(研究院), 講師 (80324630)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 肝癌 / 遺伝子変異 / 前駆細胞 / 幹細胞 / AID |
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| Research Abstract |
Although the origin of cancer cells remains mostly unsolved at present, it appears reasonable to assume that long-lived tissue stem/progenitor cells can accumulate genetic alterations and hence could be the origin of tumor cells. Whether the stepwise accumulation of genetic alterations on originally normal hepatic stem/progenitor cells contributes to the development of tumor cells, however, remains unknown. We demonstrated that engrafted hepatic progenitor cells played a role in the origin of liver tumors, including both hepatocellular carcinoma and cholangiocellular carcinoma, through the accumulation of somatic mutations in a variety of target genes.
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[Journal Article] Leptin Receptor Somatic Mutations are frequent in HCV-infected Cirrhotic Liver and associated with Hepatocellular Carcinoma2014
Author(s)
Ikeda A, Shimizu T, Matsumoto Y, Fujii Y, Eso Y, Inuzuka T, Mizuguchi A, Shimizu K, Hatano E, Uemoto S, Chiba T, Marusawa H
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Journal Title
Gastroenterology
Volume: 146
Pages: 222-232
DOI
Peer Reviewed
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[Journal Article] A model of liver carcinogenesis originating from hepatic progeniytor cells with accumulation of genetic alterations2014
Author(s)
Kim SK, Nasu A, Komori J, Shimizu T, Matsumoto Y, Minaki Y, Kohno K, Shimizu K, Uemoto S, Chiba T, Marusawa H
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Journal Title
Int J Cancer
Volume: 134
Pages: 1067-76
DOI
Peer Reviewed
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