2013 Fiscal Year Final Research Report
Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancers
| Project/Area Number |
23390200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOSHO Katsuhiko 札幌医科大学, 医学部, 講師 (10597339)
YAMAMOTO Hiroyuki 聖マリアンナ医科大学, 医学部, 准教授 (40332910)
SUZUKI Hiromu 札幌医科大学, 医学部, 教授 (20381254)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 上部消化管学 |
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| Research Abstract |
MicroRNAs (miRNA) constitute a class of small non-coding RNA molecules that function as post-transcriptional gene regulators. miRNAs can function as oncogenes or tumour suppressors. Therefore, they have been increasingly recognized as useful biomarkers for various human cancers. Metachronous gastric cancer (GC) can develop after endoscopic resection of GC and cannot be predicted based on clinical signature. We identified that DNA methylation of microRNA-34b/c (miR-34b/c) in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC. With regard to colorectal cancers (CRCs), using miRNA array analysis, we recently discovered that microRNA-31 (miR-31) expression is significantly up-regulated in BRAF-mutated colorectal cancers (CRCs) compared with that in wild-type CRCs. Moreover, associations were identified between miR-31 expression, proximal tumor location and poor prognosis for CRCs. Moreover, the results of functional analysis showed that miR-31 may regulate BRAF activation and that the oncogenic role of miR-31 and its possibility of therapeutic target in CRCs. Thus, our current data suggest that miR-31 may be a diagnostic biomarker and therapeutic target in CRC. These novel data may lead to the establishment of a new therapeutic target or a theranostic procedure in gastroenterological cancers.
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[Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway2014
Author(s)
Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y.
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Journal Title
Carcinogenesis
Volume: 35
Pages: 776-783
Peer Reviewed
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[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014
Author(s)
Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y.
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Journal Title
Tumour Biol.
Volume: 35
Pages: 973-985
Peer Reviewed
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[Journal Article] HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer2014
Author(s)
Sukawa Y, Yamamoto H, Nosho K, Ito M, Igarashi H, Naito T, Mitsuhashi K, Matsunaga Y, Takahashi T, Mikami M, Adachi Y, Suzuki H, Shinomura Y.
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Journal Title
Digestion
Volume: 89
Pages: 12-17
Peer Reviewed
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[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013
Author(s)
Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
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Journal Title
J Gastroenterol
Volume: (in press)
Peer Reviewed
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[Journal Article] Alterations in the HER2-PI3K-Akt pathway in gastric cancer2012
Author(s)
Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y.
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Journal Title
World J Gastroenterol
Volume: 18
Pages: 6577-6586
Peer Reviewed
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[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012
Author(s)
Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.
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Journal Title
Cancer Res.
Volume: 72
Pages: 1126-1136
Peer Reviewed
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[Journal Article] Profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011
Author(s)
Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano H, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M.
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Journal Title
Cancer Res.
Volume: 71
Pages: 5646-58
Peer Reviewed
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[Presentation] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
Author(s)
鈴木 拓,新沼 猛,野島正寛,丸山玲緒,山本英一郎,甲斐正広,能正勝彦,山本博幸,時野隆至,今井浩三,篠村恭久
Organizer
第71回日本癌学会学術集会
Place of Presentation
札幌
Year and Date
20120900
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