2013 Fiscal Year Final Research Report
Developing successful immunomodulatory therapies against ventricular remodeling after myocardial infarction
| Project/Area Number |
23390217
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SANO MOTOAKI 慶應義塾大学, 医学部, 准教授 (30265798)
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| Co-Investigator(Renkei-kenkyūsha) |
YAN Xiaoxiang 慶應義塾大学, 医学部, 大学院生 (90594979)
ANZAI Atsushi 慶應義塾大学, 医学部, 助教 (50528164)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 心筋梗塞 / 心不全 / 免疫 |
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| Research Abstract |
Left ventricular (LV) remodeling leads to chronic heart failure and is a main determinant of morbidity and mortality after myocardial infarction (MI). Mice with DC ablation showed deteriorated LV function and remodeling concomitant with enhanced expression of IL-1beta, IL-18, and TNF-alpha, prolonged extracellular matrix degradation, marked infiltration of proinflammatory monocytes. A deficiency of gamma-delta T cells improved survival, limiting infarct expansion and fibrosis in noninfarcted myocardium and alleviating LV dilatation and systolic dysfunction after MI. IL-17A-producing gamma-delta T cells promotes sustained infiltration of neutrophils and macrophages, , aggravating cardiomyocyte death, and enhancing fibroblast proliferation. Depletion of NK cells from mice exhibited severe respiratory. Adoptive transfer of NK cells from wild-type mice, but not from IL-10 knockout mice, into the NK cell-depleted mice rescued the respiratory phenotype.
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[Journal Article] Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction2014
Author(s)
Yan X, Hegab AE, Endo J, Anzai A, Matsuhashi T, Katsumata Y, Ito K, Yamamoto T, Betsuyaku T, Shinmura K, Shen W, Vivier E, Fukuda K, Sano M
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Journal Title
Circ Res
Volume: 114(4)
Pages: 637-49
DOI
Peer Reviewed
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[Journal Article] Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction2013
Author(s)
Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, Yamamoto T, Takeshima A, Shinmura K, Shen W, Fukuda K, Sano M
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Journal Title
J Mol Cell Cardiol
Volume: 62
Pages: 24-35
DOI
Peer Reviewed
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[Journal Article] Deleterious effect of the IL-23/IL-17A axis and γ δ T cells on left ventricular remodeling after myocardial infarction2012
Author(s)
Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, Anzai A, Endo J, Tamura Y, Kimura K, Fujita J, Shinmura K, Shen W, Yoshimura A, Fukuda K, Sano M
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Journal Title
J Am Heart Assoc
Volume: 1(5)
Pages: e004408
DOI
Peer Reviewed
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[Journal Article] Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling2012
Author(s)
Anzai A, Anzai T, Nagai S, Maekawa Y, Naito K, Kaneko H, Sugano Y, Takahashi T, Abe H, Mochizuki S, Sano M, Yoshikawa T, Okada Y, Koyasu S, Ogawa S, Fukuda K
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Journal Title
Circulation
Volume: 125(10)
Pages: 1234-45
DOI
Peer Reviewed
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[Presentation] Dendritic Cell is an Immunoprotective Regulator in Post-Infarction Healing and Left Ventricular Remodeling2011
Author(s)
Anzai A, Anzai T, Nagai S, Maekawa Y, Sano M, Yoshikawa T, Koyasu S, Ogawa S, Fukuda K
Organizer
American Heart Association-Scientific Sessions
Place of Presentation
Orlando, Florida, USA
Year and Date
2011-11-15
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