2014 Fiscal Year Final Research Report
Role of fibroblast growth factors in pathogenesis of lung cancer
| Project/Area Number |
23390218
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | 線維芽細胞増殖因子 |
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| Outline of Final Research Achievements |
Recent progress is remarkable in molecular target therapy of lung cancer. The signaling of fibroblast growth factor (FGF) signaling has been interested in many cancers including lung cancer. We have developed the mouse model of lung adenocarcinoma by overexpressing FGF9 in lung epithelial specific manner. Using that model, we have investigated the molecular mechanism of FGF9-induced lung cancer by identified the putative receptor of this pathway. We have also tested the several potential drugs as novel FGFR targeting therapy. We have also characterized the patients of lung cancer with overexpression of FGF9.
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| Free Research Field |
呼吸器内科学
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