2013 Fiscal Year Final Research Report
Clinical application and expression mechanisms for KL-6/MUC1 having a selectin ligand
| Project/Area Number |
23390222
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Tetsuya 高知大学, 教育研究部医療学系, 准教授 (30274377)
IKEZOE Takayuki 高知大学, 教育研究部医療学系, 講師 (80294833)
OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | バイオマーカー / ムチン / KL-6 / 肺障害 |
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| Research Abstract |
DIC (blood coagulation occurring in vessels) is an important prognostic factor in a severe lung injury called acute respiratory distress syndrome (ARDS). A retrospective study demonstrated that KL-6/MUC1 having a selectin ligand (SLAK) can predict the onset of DIC in ARDS. The SLAK had the better sensitivity and specificity for prediction of mortality than previously known factors and thus is a good prognostic biomarker in ARDS. During investigation on the mechanism for the synthesis of the molecules, we demonstrated that KL-6 could be expressed in mice expressing the human MUC1, although KL-6 is never expressed in mice. We also demonstrated that KL-6 could be a biomarker in mouse models of acute lung injury and bleomycin pulmonary fibrosis by using this transgenic mouse.
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Author(s)
Takahashi T, Serada S, Ako M, Fujimoto M, Miyazaki Y, Nakatsuka R, Ikezoe T, Yokoyama A, Taguchi T, Shimada K, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Do ki Y, Naka T, Nishida T
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Journal Title
Int J Cancer
Volume: 133
Pages: 2737-43
Peer Reviewed
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[Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer2012
Author(s)
Tanaka S, Hattori N, Ishikawa N, Sho da H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyam a A, Kohno N
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Journal Title
Int J Cancer
Volume: 130
Pages: 377-87
Peer Reviewed
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[Journal Article] Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels2012
Author(s)
Horimasu Y, Hattori N, Ishikawa N, K awase S, Tanaka S, Yoshioka K, Yokoy ama A, Kohno N, Bonella F, Guzman J, Ohshimo S, Costabel U
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Journal Title
Respir Med
Volume: 106
Pages: 1756-64
DOI
Peer Reviewed
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[Journal Article] Change in serum KL-6 level from baseline is useful for predicting life-threatening EGF R-TKIs induced interstitial lung disease2011
Author(s)
Kawase S, Hattori N, Ishikawa N, Hor imasu Y, Fujitaka K, Furonaka O, Isobe T, Miyoshi S, Hamada H, Yamane T, Yokoyama A, Kohno N
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Journal Title
Respir Res
Volume: 12
Pages: 97
Peer Reviewed
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[Presentation] COPDにおける肺胞上皮マーカーの検討2012
Author(s)
大西広志, 山根高, 濱田典彦, 金月恵, 穴吹和貴, 荒川悠, 酒井瑞, 塩田直樹, 窪田哲也, 横山彰仁
Organizer
第52回日本呼吸器学会学術講演会
Place of Presentation
神戸コンベンションセンター, 神戸
Year and Date
20120420-22
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