2013 Fiscal Year Final Research Report
The mechanism of regulation to occur the migraine
| Project/Area Number |
23390229
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMADA Hideomi 東京大学, 医学部附属病院, 助教 (60396752)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Jun 東京大学, 医学部, 講師 (10211252)
HORITA Shoko 東京大学, 医学部, 助教 (20534895)
SEKI George 東京大学, 医学部, 講師 (30206619)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKUNAGA Katsushi 東京大学, 医学部, 教授 (40163977)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | NBCe1 / IRBIT / 片頭痛 |
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| Research Abstract |
For pathogenic mechanism of migraine, NBCe1 presents nerve synaptic cleft side in the membrane of the glia-cells. Genetic abnormalities of the NBCe1 cause proximal renal tubular acidosis in an autosomal recessive. We presented the possibility of onset migraine that this NBCe1 adjusts pH the synaptic cleft.
Mutations K558R, reported a SNP in the database, is shown less than half functions as WT. Other Bicarbonate transporters have known dimmer-form and Dominant Negative(DN) effect. We think that NBCe1 is also dimmer-form, must have DN effect. We show that co-expressed WT and L522P mutations (No expression the membrane) clearly decreases the function of NBCe1. We lead the conclusion that the migraine possibility of NBCe1 dysfunction may be more frequent as expected.
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[Journal Article] Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the Nitric Oxide/ Guanosine 3', 5'-cyclic monophosphate pathway2014
Author(s)
Shirai A, Yamazaki O, Horita S, Nakamura M, Satoh N, Yamada H, Suzuki M, Kudo A, Kawakami H, Hofmann F, Nishiyama A, Kume H, Enomoto Y, Homma Y, Seki G
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Journal Title
J Am Soc Nephrol
Volume: (in press)
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[Journal Article] Mutation of the renal Mg2+ transporter SLC41A1 in a nephronophthisis-like phenotype2013
Author(s)
Hurd TW, Edgar Otto EA, Mishima E, Gee HY, Hana Inoue4, Inazu M, Yamada H, Halbritter J, Seki G, Konishi M, Zhou W, Yamane T, Murakami S, Caridi G, Ghiggeri G, Abe T, Hildeb F
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Journal Title
J Am Soc Nephrol
Volume: 24
Pages: 967-77
DOI
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[Journal Article] Severe Metabolic Acidosis Causes Early Lethality in NBC1 W516X Knock-in Mice as a Model of Human Isolated Proximal Renal Tubular Acidosis2011
Author(s)
Lo Y, BS, Yang S, Seki G, Yamada H, Horita S, Yamazaki O, Fujita T, MD, Usui T, Tsai J, Yu I, PhD6, Lin S, Lin S
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Journal Title
Kidney Int
Volume: 79
Pages: 730-741
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[Journal Article] Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPAR・-dependent non-genomic signaling2011
Author(s)
Endo Y, Suzuki M, Yamada H, Horita S, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
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Journal Title
Cell Metab
Volume: 13
Pages: 550-561
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[Presentation] インスリン抵抗性におけるインスリンの近位尿細管輸送亢進作用機序2012
Author(s)
中村元信, 山崎修, 白井雅弓, 山田秀臣, 堀田晶子, 鈴木正志, 榎本裕, 久米春喜, 本間之夫, 関常司, 藤田敏郎
Organizer
第55回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2012-06-02
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[Presentation] アンジオテンシン(Ang)IIのヒト近位尿細管特異的作用機序2012
Author(s)
白井雅弓, 山崎修, 中村元信, 山田秀臣, 堀田晶子, 鈴木正志, 榎本 裕, 久米春喜, 本間之夫, Franz Hofmann, 関常司, 藤田敏郎
Organizer
第55回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2012-06-01
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[Presentation] インスリンの近位尿細管輸送亢進作用はインスリン抵抗性でも保たれる2011
Author(s)
中村元信, 山崎修, 白井雅弓, 山田秀臣, 堀田晶子, 鈴木正志, 榎本裕, 久米春喜, 本間之夫, 関常司, 藤田敏郎
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2011-06-16
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[Presentation] アンジオテンシンIIのヒト近位尿細管作用におけるNO/sGC/cGMP経路の意義2011
Author(s)
白井雅弓, 山崎修, 中村元信, 山田秀臣, 堀田晶子, 鈴木正志, 榎本裕, 久米春喜, 本間之夫, 関常司, 藤田敏郎
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2011-06-15
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