2013 Fiscal Year Final Research Report
Regenerative therapy for Alzheimer's disease and cerebral amyloid angiopathy
| Project/Area Number |
23390233
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Cardiovascular Center Research Institute (2013)
Foundation for Biomedical Research and Innovation (2012)
Kyoto University (2011) |
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Principal Investigator |
IHARA Masafumi 独立行政法人国立循環器病研究センター, 病院, 医長 (00372590)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMIMOTO Hidekazu 三重大学, 大学院・医学系研究科・ 神経感覚医学講座神経病態内科学, 教授 (80324648)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アルツハイマー病 / アミロイド血管症 / βアミロイド / シロスタゾール / 臨床試験 / 医師主導治験 / 微小梗塞 / モデルマウス |
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| Research Abstract |
Dementia will become one of the most important health problems worldwide. The discouraging results of the immunotherapy clinical trials for Alzheimer's disease have shifted scientific attention from the mechanism underlying beta amyloid (Abeta) synthesis toward clearance. Arterial pulsations may be the motive force for the drainage of interstitial fluid and solutes. As arteries stiffen with age or with other co-morbid factors, the amplitude of pulsations is reduced, perivascular drainage of Abeta becomes less efficient, and insoluble Abeta is deposited in the drainage pathways. Therefore, therapeutic strategies that enhance the patency of this perivascular drainage pathway with vasoactive drugs may facilitate Abeta removal and help prevent cognitive decline in the elderly. Based on this emerging paradigm, we will start a clinical trial to determine whether such a hemodynamic strategy is effective to halt cognitive decline as a preemptive medicine.
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[Journal Article] Cilostazol add-on therapy in patients with mild dementia receiving donepezil : a retrospective study2014
Author(s)
Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, Takahashi Y, Tsuji M, Kasahara Y, Takata Y, Okada M
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Journal Title
PloS ONE
Volume: 9(2)
Pages: e89516
DOI
Peer Reviewed
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[Journal Article] Selective white matter abnormalities in a novel rat model of vascular dementia2012
Author(s)
Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
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Journal Title
Neurobiol Aging
Volume: 33(5) : 1012
Pages: e25-35
DOI
Peer Reviewed
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[Journal Article] Cerebral hypoperfusion induces microinfarcts in cerebral amyloid angiopathy2012
Author(s)
Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M
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Journal Title
Acta Neuropathol
Volume: 123(3)
Pages: 381-394
DOI
Peer Reviewed
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[Journal Article] Watershed Infarcts in a multiple microembolic model of monkey2011
Author(s)
Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
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Journal Title
Neurosci Lett
Volume: 499(2)
Pages: 80-83
DOI
Peer Reviewed
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[Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice2011
Author(s)
Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
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Journal Title
PLoS ONE
Volume: 6(1)
Pages: e16567
DOI
Peer Reviewed
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[Journal Article] Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β -amyloid
Author(s)
Maki T, Okamoto Y, Carare R, Hase Y, Hattori Y, Hawkes C, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda, H, Taguchi A, Takahashi R, Miyakawa T, Kalaria R, Lo E, Arai K, Ihara M
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Journal Title
Ann Clin Transl Neurol
Volume: (in press)
Peer Reviewed
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