The significance of vaspin in metabolic syndrome and drug discovery

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Okayama University
• Principal Investigator: WADA Jun 岡山大学, 医歯(薬)学総合研究科, 准教授 (30294408)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: メタボリックシンドローム / インスリン抵抗性 / アディポカイン / バスピン / 糖尿病 / 脂質異常症 / 高血圧 / 肥満症

Research Abstract

Vaspin is a novel adipocytokine, which was identified from visceral adipose tissues in obese rats. Vaspin ameliorates the insulin resistance and development of atherosclerosis in metabolic syndrome. Vaspin circulates in the sera of human subjects and it positively correlated with body mass index and degree of insulin resistance. Serum levels of vaspin were higher in patients with type 2 diabetes compared with normal healthy subjects. The regulation of serum concentration of vaspin is different from leptin and adiponectin, and vaspin may be a new therapeutic target for metabolic syndrome.

Research Products

• [Journal Article] Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy (2014)
  • Author(s): Watanabe M, Nakatsuka A, Murakami K, Inoue K, Terami T, Higuchi C, Katayama A, Teshigawara S, Eguchi J, Ogawa D, Watanabe E, Wada J, Makino H
  • Journal Title: PLoS ONE Volume: 9(3) Pages: e92647
  • DOI: 10.1371/journal.pone.0092647
  • Peer Reviewed
• [Journal Article] Nuclear hormone receptor expression in mouse kidney and renal cell lines (2014)
  • Author(s): Ogawa D, Eguchi J, Wada J, Terami N, Hatanaka T, Tachibana H, Nakatsuka A, Horiguchi CS, Nishii N, Makino H
  • Journal Title: PLoS ONE Volume: 9(1) Pages: e85594
  • DOI: 10.1371/journal.pone.0085594
  • Peer Reviewed
• [Journal Article] Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice (2014)
  • Author(s): Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horigushi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H
  • Journal Title: Am J Physiol Renal Physiol Volume: 306 Pages: F105-F115
  • DOI: 10.1152/ajprenal.00034.2013
  • Peer Reviewed
• [Journal Article] Long-term effect of cinacalcet hydrochloride on abdominal aortic calcification in patients on hemodialysis with secondary hyperparathyroidism (2013)
  • Author(s): Nakayama K, Nakao K, Takatori Y, Inoue J, Kojo S, Akagi S, Fukushima M, Wada J, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 7 Pages: 25-33
  • DOI: 10.2147/IJNRD.S54731
  • Peer Reviewed
• [Journal Article] Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes (2013)
  • Author(s): Terami T, Wada J, Inoue K, Nakatsuka A, Ogawa D, Teshigawara S, Murakami K, Katayama A, Eguchi J, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 6 Pages: 233-240
  • DOI: 10.2147/IJNRD.S51829
  • Peer Reviewed
• [Journal Article] Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease (2013)
  • Author(s): Kurose Y, Wada J, Kanzaki M, Teshigawara S, Nakatsuka A, Murakami K, Inoue K, Terami T, Katayama A, Watanabe M, Higushi C, Eguchi J, Miyatake N, Makino H
  • Journal Title: BMC Nephrol 14 Volume: 14 Pages: 23
  • DOI: 10.1186/1471-2369-14-23
  • Peer Reviewed
• [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex (2013)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Ogawa D, Matsuki Y, Hiramatsu R, Tagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Circ Res Volume: 112(5) Pages: 771-780
  • DOI: 10.1161/CIRCRESAHA.111.300049
  • Peer Reviewed
• [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension : Abdominal fat Depot Intervention Program of Okayama (ADIPO) (2013)
  • Author(s): Murakami K, Wada J, Ogawa D, Horiguchi CS, Miyoshi T, Sasaki M, Uchida HA, Nakamura Y, Makino H
  • Journal Title: Diab Vasc Dis Res Volume: 10(1) Pages: 93-96
  • DOI: 10.1177/1479164112444640
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice (2012)
  • Author(s): Sato-Horiguchi C, Ogawa D, Wada J, Tachibana H, Kodera R, Eguchi J, Nakatsuka A, Terami N, Shikata K, Makino H
  • Journal Title: Nephron Exp Nephrol Volume: 121(3-4) Pages: e97-e108
  • DOI: 10.1159/000343102
  • Peer Reviewed
• [Journal Article] The serum vaspin levels are reduced in Japanese chronic hemodialysis patients (2012)
  • Author(s): Inoue J, Wada J, Teshigawara S, Hida K, Nakatsuka A, Takatori U, Kojo S, Akagi S, Nakao K, Miyatake N, McDonald JF, Makino H
  • Journal Title: BMC Nephrol Volume: 13(1) Pages: 163
  • DOI: 10.1186/1471-2369-13-163
  • Peer Reviewed
• [Journal Article] Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy (2012)
  • Author(s): Tachibana H, Ogawa D, Matsushita Y, Bruemmer D, Wada J, Teshigawara S, Eguchi J, Horiguchi CS, Uchida HA, Shikata K, Makino H
  • Journal Title: J Am Soc Nephrol Volume: 23(11) Pages: 1835-1846
  • DOI: 10.1681/ASN.2012010022
  • Peer Reviewed
• [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex (2012)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Diabetes Volume: 61(11) Pages: 2823-2832
  • DOI: 10.2337/db12-0232
  • Peer Reviewed
• [Journal Article] The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome : a randomized controlled trial (2012)
  • Author(s): Kanzaki M, Wada J, Kikumoto Y, Akagi S, Nakao K, Sugiyama H, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 5 Pages: 91-96
  • DOI: 10.2147/IJNRD.S32191
  • Peer Reviewed
• [Journal Article] Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice (2012)
  • Author(s): Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K
  • Journal Title: Hepatology Volume: 56(3) Pages: 912-921
  • DOI: 10.1002/hep.25782
  • Peer Reviewed
• [Journal Article] Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population (2012)
  • Author(s): Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Inoe K, Terami T, Katayama A, Iseda I, Matsushita Y, Miyatake N, McDonald JF, Hotta K, Makino H
  • Journal Title: J Clin Endocrinol Metab Volume: 97(7) Pages: E1202-1207
  • DOI: 10.1210/jc.2011-3297
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes (2012)
  • Author(s): Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, Inoue K, Terami T, Katayama A, Eguchi J, Akiba H, Yagita H, Makino H
  • Journal Title: Endocrinology Volume: 153(2) Pages: 612-620
  • DOI: 10.1210/en.2011-1579
  • Peer Reviewed
• [Journal Article] Impact of circulating vaspin levels on metabolic variables in elderly twins (2012)
  • Author(s): Hida K, Poulsen P, Teshigawara S, Nilsson E, Friedrichsen M, Ribel-Madsen R, Grunnet L, Lund SS, Wada J, Vaag A
  • Journal Title: Diabetologia Volume: 55(2) Pages: 530-532
  • DOI: 10.1007/s00125-011-2385-0
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 Cip1 pathway in adipocytes (2012)
  • Author(s): Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
  • Journal Title: J Pathol Volume: 226(5) Pages: 784-795
  • DOI: 10.1002/path.3001
  • Peer Reviewed
• [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells (2011)
  • Author(s): Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K, Makino H
  • Journal Title: Exp Diabetes Res Volume: 2011 Pages: 534872
  • DOI: 10.1155/2011/534872
  • Peer Reviewed
• [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management : a randomized controlled trial (2011)
  • Author(s): Takatori Y, Akagi S, Sugiyama H, Inoue J, Kojo S, Morinaga H, Nakao K, Wada J, Makino H
  • Journal Title: Clin J Am Soc Nephrol Volume: 6(6) Pages: 1337-1344
  • DOI: 10.2215/CJN.10041110
  • Peer Reviewed
• [Journal Article] Urinary fetuin-A is a novel marker for diabetic neohropathy in type 2 diabetes identified by lectin microarray
  • Author(s): Inoue K, Wada J, Eguchi J, Nakatsuka A, Teshigawara S, Murakami K, Ogawa D, Terami T, Katayama A, Tone A, Iseda I, Hida K, Yamada M, Ogawa T, Makino H
  • Journal Title: PLoS ONE Volume: 8(10) Pages: e77118
  • DOI: 10.1371/journal.pone.0077118
  • Peer Reviewed
• [Presentation] T Soluble form of transmembrane protein, Gpnmb, is a novel adipokine with a protective role in fatty liver diseases in obesity (2013)
  • Author(s): Katayama A, Wada J, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Teshigawara S, Terami T, Inoue K, Hida K, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 20130127-0201
• [Presentation] The pathological role of galectin-9 in metabolic syndrome (2013)
  • Author(s): Teshigawara S, Wada J, Kanzaki M, Nakatsuka A, Murakami K, Katayama A, Terami T, Inoue K, Eguchi J, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 20130127-0201
• [Presentation] Phosphatidylethanolamine N-methyltransferase (PEMT) deficiency improves obesity and insulin resistance associated with unexpected progression of steatoheptitis (2013)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Kanzaki M, Terami T, Katayama A, Eguchi J, Makino H
  • Organizer: Keystone Symposia 'Adipose Tissue Biology'
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 20130127-0201
• [Presentation] ACAM (Adipocyte Adhesion Molecule) / CLMP Inhibits Adipocyte Hypertrophy in Obesity (2013)
  • Author(s): Murakami K, Wada J, Eguchi J, Ogawa D, Terami T, Terami N, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-23
• [Presentation] Phosphatidylethanolamine N-Methyltransferase (PEMT) Deficiency Protects from Obesity and Insulin Resistance but Promote Steatoheptitis with Tumorigenesis (2013)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Terami T, Eguchi J, Ogawa D, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-23
• [Presentation] Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines (2013)
  • Author(s): Ogawa D, Eguchi J, Tachibana H, Sato-Horiguchi C, Hatanaka T, Nakatsuka A , Wada J, Makino H
  • Organizer: ADA 73th Scientific Session
  • Place of Presentation: Chicago
  • Year and Date: 2013-06-22
• [Presentation] Identification of transmembrnane proteins expressed in adipocytes under obese-state and the roles soluble forms in fat accumulation (2012)
  • Author(s): Wada J
  • Organizer: International Symposium for the Study ofObesity "Translational Science and Epidemiology on Adipomedicine; From Lipodystrophy to Obesity"
  • Place of Presentation: Shiran Kaikan of Kyoto University, Kyoto
  • Year and Date: 20121013-14
  • Invited
• [Presentation] The pathological role of galectin-9 in metabolic syndrome; Modulation of inflammatory responses in liver and adipose tissue (2012)
  • Author(s): Kanzaki M, Wada J, Nakatsuka A, Murakami K, Teshigawara S, Katayama A, Terami T, Inoue K, Eguchi J, Makino H
  • Organizer: Keystone Symposia, Genetic and Molecular Basis of Obesity and Body Weight Regulation
  • Place of Presentation: Santa Fe, New Mexico, USA
  • Year and Date: 2012-12-01
• [Presentation] Phosphatidylethanolamine N-methyltransferase (PEMT) deficiency protects from obesity and insulin resistance but aggravates non-alcoholic steatoheptitis (NASH) (2012)
  • Author(s): Nakatsuka A, Wada J, Murakami K, Kanzaki M, Terami T, Katayama A, Eguchi J, Makino H
  • Organizer: Keystone Symposia, Genetic and Molecular Basis of Obesity and Body Weight Regulation
  • Place of Presentation: Santa Fe, New Mexico, USA
  • Year and Date: 2012-12-01