2013 Fiscal Year Final Research Report
Research on a novel selective androgen receptor modulator, S42 for the development of life-related drug.
| Project/Area Number |
23390248
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NOMIYAMA Takashi 福岡大学, 医学部, 准教授 (10532559)
TANAKA Tomoko 福岡大学, 医学部, 助教 (10380528)
MURASE Kunitaka 福岡大学, 医学部, 助教 (30712517)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生活習慣病 / アンドロゲン / SARM / high fat diet / obesity / androgen receptor |
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| Research Abstract |
We examined whether a SARM (selective androgen receptor modulator) compound, S42 which we had identified, could have some beneficial effect on obesity and glucose tolerance using male mouse model fed high fat diet (FAD). In castrated male mice fed HFD, DHT administration aggravated the HFD-induced visceral obesity, glucose intolerance and fatty liver. However, such aggravation was not observed with S42 administration. In non-castrated male mice fed HFD, S42 itself could manifest beneficial effects including the decrease of the body fat etc. S42 could be a good candidate chemical for developing innovative drugs for life-related diseases.
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[Journal Article] Identification of endocrine disrupting chemicals activating SXR-mediated transactivation of CYP3A and CYP7A12013
Author(s)
Zhou T, Cong S, Sun S, Sun H, Zou R, Wang S, Wang C, Jiao J, Goto K, Nawata H, Yanase T, Zhao Y
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Journal Title
Mol Cell Endocrinol
Volume: 365 (1)
Pages: 36-43
Peer Reviewed
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[Journal Article] Perilipin 5, a lipid droplet-binding protein, protects the heart from oxidative burden by sequestering fatty acid from excessive oxidation2012
Author(s)
Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H, Nomura M,, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y, Hashimoto T, Sakai F, Hirose Yanase T F, Osumi T
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Journal Title
J Biol Chem
Volume: 287(28)
Pages: 23852-63
Peer Reviewed
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