2013 Fiscal Year Final Research Report
Comprehensive genetic analysis identifying novel genetic abnormalities responsible for myeloproliferative neoplasm
| Project/Area Number |
23390255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKU Eijiro 久留米大学, 医学部, 助教 (10569429)
MIZUNO Shinichi 九州大学, 先端医療イノベーションセンター, 准教授 (40569430)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 血液腫瘍学 / 遺伝子変異 |
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| Research Abstract |
In this study, we performed a comprehensive genetic analysis by using a newly developed system for fusion-gene detection and whole exome analysis, in order to identify novel genetic abnormalities responsible for myeloproliferative neoplasm (MPN) and to develop a new therapeutic option. We could detect several candidate regions with altered genomic structures which would contribute to produce novel fusion-genes. In addition, many novel missense mutations were found in MPN cases by whole exome analysis, however, they are not shared among cases. We are applying CRISPR method to patients' derived iPSs in order to clarify genetic functions of those mutations. Furthermore, we found out that peptides derived from those mutations could be presented to patients' HLA molecules and be recognized by T cells. We are preparing a protocol to provide patients a novel therapeutic option as genetic analysis-based personalized immunotherapy.
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Author(s)
Nagafuji K, Miyamoto T, Eto T, Kamimura T, Taniguchi S, Okamura T, Ohtsuka E, Yoshida T, Higuchi M, Yoshimoto G, Fujisaki T, Abe Y, Takamatsu Y, Yokota S, Akashi K, Harada M. (16名, 6番目)
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Journal Title
Int J Hematol
Volume: 97
Pages: 139-43
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[Journal Article] Unrelated cord blood transplantation for patients with adult T-cell leukemia/lymphoma : experience at a single institute2012
Author(s)
Nakamura T, Oku E, Nomura K, Morishige S, Takata Y, Seki R, Imamura R, Osaki K, Hashiguchi M, Yakushiji K, Mouri F, Mizuno S, Yoshimoto K, Ohshima K, Nagafuji K, Okamura T. (16名, ラスト)
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Journal Title
Int J Hematol
Volume: 96
Pages: 657-63
DOI
Peer Reviewed
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