2013 Fiscal Year Final Research Report
What is a ligand fro LMIR, regulating allery and inflammation?
| Project/Area Number |
23390257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KITAURA JIRO 東京大学, 医科学研究所, 准教授 (30282651)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Toshio 東京大学, 医科学研究所, 教授 (20282527)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アレルギー / 炎症 / 免疫 / ペア型レセプター |
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| Research Abstract |
In this study, we identify ceramide as a ligand for mouse LMIR3/CD300f by using both physical binding and functional reporter assays. Importantly, the interaction between extracellular ceramide and LMIR3 suppresses IgE- and mast cell-dependent allergic responses. Moreover, we identify sphingomyelin and ceramide as ligands for human LMIR3/CD300f. On the other hand, we identify phosphatidylethanolamine and apoptotic cells as possible ligands for human CD300a and CD300c. These results indicated that specific lipids are physiological ligands for LMIR/CD300.
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[Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation2014
Author(s)
Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T & Kitaura J
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Journal Title
J Allergy Clin Immunol
Volume: 133
Pages: 270-273
DOI
Peer Reviewed
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[Journal Article] Human CD300C Delivers an FceReceptor- γ -dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition2013
Author(s)
Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T & Kitaura J
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Journal Title
J Biol Chem
Volume: 288
Pages: 7662-7675
DOI
Peer Reviewed
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[Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide2012
Author(s)
Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T & Kitaura J
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Journal Title
Immunity
Volume: 37
Pages: 827-839
DOI
Peer Reviewed
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[Journal Article] A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis2012
Author(s)
Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T & Kitaura J
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Journal Title
J Immunol
Volume: 189
Pages: 1773-1779
DOI
Peer Reviewed
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