2013 Fiscal Year Final Research Report
MAIT cells in autoimmune diseases
| Project/Area Number |
23390261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Juntendo University (2013)
National Center of Neurology and Psychiatry (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | MAIT細胞 / 自己免疫 / 腸内細菌 |
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| Research Abstract |
Mucosal associated invariant T (MAIT) cells are restricted by MHC-related molecule-1(MR1) and express an invariant TCR chain. MAIT cells are selected in the thymus in an MR1-dependent manner, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion. We demonstrated that MAIT cells contribute to the arthritis severity of collagen induced arthritis and antibody induced arthritis, mostly by augmenting joint inflammation in the effector phase of arthritis. Furthermore, we showed that the frequency of MAIT cells in peripheral blood is reduced in patients with rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. The proliferative response of MAIT cells upon CD3 stimulation or cytokine stimulation was decreased in addition to the increase of apoptosis in lupus patients. The role of MAIT cells in lupus pathogenesis remains investigated.
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Research Products
(44 results)
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[Journal Article] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica2013
Author(s)
Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamaoto T, Murata M, Toda T, Miyake S, Yamamura T
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Journal Title
PLOS one
Volume: 8(12)
Pages: e83036
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[Journal Article] Synthesis and biological evaluation of truncated a-galactosylceramide derivatives focusing on cytokine induction profile2012
Author(s)
Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H
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Journal Title
Bloorg Med Cehm
Volume: 20
Pages: 2850-2859
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[Journal Article] CCR2+CCR5+ T cells producing matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis2012
Author(s)
Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
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Journal Title
J Immunol
Volume: 189
Pages: 5057-5065
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[Journal Article] Differential effects of fingolimod on B-cell populations in multiple sclerosis
Author(s)
akamura M, Matsuoka T, Chihara N, Miyae S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T
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Journal Title
Mult Scler
Volume: (in press)
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[Presentation] IL-6 Signaling As a Potential Therapeutic Target In Relapsing-Remitting Multiple Sclerosis with An Increased Plasmablast Frequency2013
Author(s)
Nakamura M, Matsuoka T, Araki M, Lin Y, Sato W, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T
Organizer
PACTRIMS 2013
Place of Presentation
Kyoto, Japan
Year and Date
2013-11-06
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