Transcriptional regulation of cardiovascular development

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390274
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: National Cardiovascular Center Research Institute (2013); Nara Medical University (2011-2012)
• Principal Investigator: NAKAGAWA Osamu 独立行政法人国立循環器病研究センター, 研究所, 部長 (40283593)
• Co-Investigator(Kenkyū-buntansha): SAKABE Masahide 奈良県立医科大学, 医学部, 助教 (00525983) ; HAYASHI Hisaki 愛知医科大学, 医学部, 講師 (30533715) ; KONISHI Noboru 奈良県立医科大学, 医学部, 教授 (20145832) ; HAYASHI Tamaki 奈良県立医科大学, 医学部, 助教 (50351648) ; YAMAGISHI Hiroyuki 慶應義塾大学, 医学部, 准教授 (40255500)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 心血管発生 / 形態形成 / 転写調節因子 / 血管内皮細胞

Outline of Final Research Achievements

Proper formation of the heart and blood vessels is achieved by the combinatory functions of various cellular molecules. Among those, transcription factors play central roles in regulating when, where and how much those functional molecules are produced. We previously identified the Hrt/Hey family of transcription factors and reported their significance during cardiovascular differentiation (acquirement of proper cell characteristics) and morphogenesis (construction of functional architecture). By using Hrt/Hey deficient model mice and molecular biological techniques in this study, we further demonstrated that the functions of Hrt/Hey in endothelial cells were essential for embryonic vascular formation.

Free Research Field

心血管発生医学