2013 Fiscal Year Final Research Report
ROLES OF EPIGENETIC MECHANISM IN HOMEOSTATIC CELL-CYCLE CONTROL IN NEURONAL STEM CELLS
| Project/Area Number |
23390276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOSAKI Kenjiro 慶應義塾大学, 医学部, 教授 (30234743)
MITSUHASHI Takayuki 慶應義塾大学, 医学部, 講師 (80338110)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 小児神経学 |
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| Research Abstract |
Epigenetic mechanisms are considered to be a putative machinery for controlling cell cycle kinetics of neuronal progenitor cells (NPCs) that forms cerebral cortex in mammals. According to our previous results from specific gene overexpression/loss-of-function experiments and in utero exposure to dioxin analysis, we have observed buffering phenomena to maintain normal cell cycle length of the NPCs by adjusting lengths of each phase of the cell cycle. Taken together, we investigated roles of epigenetic mechanisms in cell cycle regulation in NPCs which forms cerebral cortex in vivo. Especially, the research focus was put upon the regulation of histone acetylation by histone deacetylase.
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