2013 Fiscal Year Final Research Report
Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology
| Project/Area Number |
23390280
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KAMBE Naotomo 千葉大学, 医学(系)研究科(研究院), 准教授 (50335254)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUE Hiroyuki 千葉大学, 大学院・医学研究院, 教授 (10250424)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIKOMORI Ryuta 京都大学, 大学院・医学研究科, 准教授 (70359800)
OHARA Osamu かずさ DNA 研究所, ヒトゲノム研究部, 部長 (20370926)
SAITO Megumu 京都大学, iPS 研究所, 准教授 (90535486)
NAKAHATA Tatsutoshi 京都大学, iPS 研究所, 教授 (20110744)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 皮膚炎症・再生学 / 肉芽腫 / NOD2 |
|---|
| Research Abstract |
Blau syndrome and early-onset sarcoidosis (EOS) is the granulomatosis, based on the NOD2 mutation, which is spontaneously activated without external ligand. To unveil the molecular mechanism how NOD2 activation induce granuloma formation, we collected CD14 positive peripheral monocytes from the patients and analyzed the gene expression profiles. However, probably due to the quite low expression levels of NOD2 gene in the peripheral monocytes from the patients, we could not identify the difference between the patients with NOD2 mutation and normal controls to explain the granuloma formation in Blau syndrome/EOS. We will still continue the analysis for evaluating the granuloma formation, using the transient expression model with disease-associated NOD2 mutants, that was established through this project.
|
Research Products
(48 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012
Author(s)
Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Y amamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Y amanaka S, Nakahata T, Saito MK
-
Journal Title
Blood
Volume: 120
Pages: 1299-308
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 手根管長および関節エコーによる若年発症サルコイドーシスにおける関節炎病態の検討2012
Author(s)
赤池治美, 久保田知洋, 山崎雄一, 山遠剛, 野中由希子, 根路銘安仁, 嶽崎智子, 今中啓之, 池田 啓, 神戸直智, 武井修治
Organizer
第22回日本小児リウマチ学会総会・学術大会
Place of Presentation
名古屋市
Year and Date
20121005-07
-
-
-
-
-
-
-
-
-
-
-
-
-
-
