2013 Fiscal Year Final Research Report
Molecular mechanisms of regulatory B cell inhibition on skin immunological diseases
| Project/Area Number |
23390281
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba (2013)
Kanazawa University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 免疫 / B細胞 |
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| Research Abstract |
Signal transduction mechanisms responsible for IL-10 production in regulatory B cells were analyzed. BLNK is an important adaptor protein in B cell signal transduction. B cells from BLNK-deficient mice showed diminished IL-10 production in CD1dhiCD5+ B cells. Accordingly, BLNK-deficient mice exhibited augmented contact hypersensitivity response. CD1dhiCD5+ B cells from BLNK-deficient mice showed impaired Stat3 activation, which was dependent on Btk activity. Moreover, exogenous addition of IL-10 in culture markedly increased the number of IL-10-producing B cells, suggesting the presence of positive feedback loop provided by IL-10 stimulation.
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