2013 Fiscal Year Final Research Report

Diagnostic classification of pathophysiology of schizophrenia utilizing genomic information

Research Project

Project/Area Number	23390285
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	University of Tsukuba
Principal Investigator	ARINAMI TADAO 筑波大学, 医学医療系, 教授 (10212648)
Co-Investigator(Kenkyū-buntansha)	IIJIMA Yoshimi 筑波大学, 医学医療系, 助教 (70574648)
Co-Investigator(Renkei-kenkyūsha)	INADA Toshiya (財)神経研究所, 副所長 (00184721)
Project Period (FY)	2011-04-01 – 2014-03-31
Keywords	臨床精神分子遺伝学 / 統合失調症
Research Abstract	Large difference in symptoms, treatment response, and prognosis between patients with schizophrenia is assumed to be partly caused by difference in genome architecture. Recent genome analyses revealed important role of de novo mutation in sporadic cases. In familial cases, however, such breakthrough has not been discovered. Past studies indicate responsible locus in the short arm of chromosome 1 p in Japanese familial schizophrenia. To clarify path-etiology of Japanese familial schizophrenia, we screened the linkage region in the probands using next-generation sequencing and found the CELSR2 gene as a potential responsible gene of Japanese familial schizophrenia.