Investigation of brain substrates for daily living dysfunction in psychiatric disorders through real-world functional neuroimaging using near-infrared spectroscopy

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390286
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: FUKUDA Masato 群馬大学, 医学(系)研究科(研究院), 教授 (20221533)
• Co-Investigator(Kenkyū-buntansha): MIKUNI Masahiko 群馬大学, 大学院医学系研究科, 教授 (00125353) ; KAMEYAMA Masaki 群馬大学, 大学院医学系研究科, 助教 (00455982) ; TAKEI Yuichi 群馬大学, 医学部附属病院, 助教 (30455985) ; UEHARA Toru 群馬大学, 健康支援総合センター, 准教授 (60303145) ; NARITA Kosuke 群馬大学, 医学部附属病院, 講師 (70345677) ; AOYAMA Yoshiyuki 群馬大学, 医学部附属病院, 助教 (60568351) ; SUDA Masashi 群馬大学, 医学部附属病院, 助教 (30553747) ; FUJIHIRA Kazuyoshi 群馬大学, 大学院医学系研究科, 助教 (70625582)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 統合失調症 / 気分障害 / 精神疾患 / 対人関係 / 生活障害 / 近赤外線スペクトロスコピィ / 脳機能画像

Outline of Final Research Achievements

Brain substrates of social behavior were investigated using near-infrared spectroscopy (NIRS) just during the conversation. Frontal and temporal activations during the conversation were negatively correlated with negative symptoms assessed using PANSS in schizophrenia and were also negatively correlated with functional level assessed using GAF in major depressive disorder. These results demonstrate successful establishment of functional neuroimaging examination just during social behaviors, which can be called as “real-world neuroimaging” and will be available in elucidating brain mechanisms of daily living dysfunction in psychiatric disorders.

Free Research Field

精神医学