2013 Fiscal Year Final Research Report
In vivo imaging of the activity of ganma-secretase for amyloid production in Alzheimer's disease
| Project/Area Number |
23390287
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OUCHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328)
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 準教授 (20344351)
MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アルツハイマー病 / ガンマセクレターゼ |
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| Research Abstract |
Because it has been shown that the degree of beta-amyloid deposition in the Alzheimer's brain does not correlate with the deterioration of cognitive function, we aimed to examine the activity of ganma-secretase that regulates the production of beta-amyloid in vivo. The MRI probe that was designed to emit signals in high-magnetic field MRI worked in the in vitro setting failed to give enough NMR signals in the in vivo measurement, suggesting that a probe with a high permeability for cells and with a large signal-emitting power would be desirable.
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