2013 Fiscal Year Final Research Report
Functional analysis of microglia as a therapeutic target of schizophrenia
| Project/Area Number |
23390289
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SATO Kohji 浜松医科大学, 医学部, 教授 (80235340)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Norio 浜松医科大学, 医学部, 教授 (00174376)
MATSUZAKI Hideo 福井大学, 医学部, 教授 (00334970)
UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328)
NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 精神病理学 |
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| Research Abstract |
Aberrant microglial activation was recently observed in the affected brain with schizophrenia at its early developmental stage. This observation implies the involvement of pathological activation in the pathophysiology of schizophrenia. Thus the present study aimed at the investigation of molecular machinery underlying microglial activation in the pathological condition. Firstly, mice expressing fluorescein specifically in microglia were infected with poly(I:C) and model mice of schizophrenia were established. Secondarily, newly developed fluorescent imaging probe was administrated to the established schizophrenic model mice , and the activation of Caspase-1 and subsequent IL-1beta production at early phase of inflammation were visualized in vivo under two-photon microscope.
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Research Products
(10 results)
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[Journal Article] Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm2014
Author(s)
Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N
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Journal Title
PLoS One
Volume: 9
Pages: e89830
DOI
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[Journal Article] Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm2013
Author(s)
Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N
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Journal Title
PLoS One
Volume: 8
Pages: e57398
DOI
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