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2013 Fiscal Year Final Research Report

The effects of radiation on cancer metastasis

Research Project

  • PDF
Project/Area Number 23390300
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionResearch Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012-2013)
Osaka University (2011)

Principal Investigator

TESHIMA Teruki  地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 放射線治療科, 主任部長(大阪大学名誉教授) (40136049)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Masao  神戸大学, 医学(系)研究科(研究院), 教授 (50210018)
DEMIZU Yusuke  神戸大学, 医学(系)研究科(研究院), 准教授 (50452496)
MATSUURA Nariaki  大阪大学, 医学(系)研究科(研究院), 教授 (70190402)
MINAMI Kazumasa  大阪大学, 医学(系)研究科(研究院), 研究員 (90634593)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords放射線腫瘍学 / 放射線治療学 / 細胞動態解析
Research Abstract

The effects of 3 types radiation (X-ray, carbon ion beam and proton beam) on cancer metastasis were investigated in this study. As the results, the cell migration and invasion capability were increased by low dose X-ray or proton beam irradiation. On the other hand, carbon ion beam decreased these metastatic potentials. Furthermore, the cells that low dose X-ray or proton beam was irradiated enhanced the expression of FAK (Focal adhesion kinase) which had important role to form desmosome and X-ray enhanced the expression of Rho family proteins which related to regulating cytoskeleton. In case of carbon ion beam, the expressions of these proteins in the cancer cells were suppressed. This study suggested that carbon ion beam might suppressed cancer metastasis.

  • Research Products

    (10 results)

All 2014 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Attenuation of malignant phenotypes of breast cancer cells through eIF2α-mediated downregulation of Rac1 signaling2014

    • Author(s)
      Hamamura K., Minami K., Matsuura N. (他5名)
    • Journal Title

      Int. J Oncol

      Volume: 44(6) Pages: 1980-8

    • Peer Reviewed
  • [Journal Article] Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo2013

    • Author(s)
      Yokoyama Y ., Matsuura N. (他8名)
    • Journal Title

      Cancer Sci

      Volume: 104(7) Pages: 889-95

    • Peer Reviewed
  • [Journal Article] Administration of salubrinal enhances radiation-induced cell death of SW1353 Chondrosarcoma Cells2012

    • Author(s)
      Koizumi M., T eshima T . (他7名)
    • Journal Title

      Anticancer Res

      Volume: 32(9) Pages: 3667-3673

    • Peer Reviewed
  • [Journal Article] Anti-IL-6 receptor antibody does not ameliorate radiation pneumonia in mice2012

    • Author(s)
      Ogata T ., Teshima T ., Matsuura N. (他3名)
    • Journal Title

      Ex p. Ther . Med

      Volume: 4(2) Pages: 273-276

    • Peer Reviewed
  • [Journal Article] Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of lase-accelerated protons2011

    • Author(s)
      Yogo A., Teshima T . 他 11名)
    • Journal Title

      J pn. J . Of Applied Phy sics

      Volume: 50 Pages: 106404

    • Peer Reviewed
  • [Presentation] Detectability of the position of the diaphragm in the exhale CBCT for patient positioning in respiratory gated stereotactic body radiotherapy2013

    • Author(s)
      Tsujii M., Teshima T, Et al
    • Organizer
      ASTRO 55th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20130900
  • [Presentation] Modeling the agility MLC for montecarlo IMRT and VMA T calculations2013

    • Author(s)
      Ueyama S., Teshima T, Et al
    • Organizer
      AAPM 55th Annual Meeting
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      20130800
  • [Presentation] Maximizing the availability of positron emitting nuclei for proton therapy verification using different beam irradiation sequences2012

    • Author(s)
      Yagi M., Teshima T, Et al
    • Organizer
      AAPM 54th Annual Meeting
    • Place of Presentation
      Charlotte USA
    • Year and Date
      20120000
  • [Presentation] Cardenes HR., DesRosiers C. Impact of heterogeneity corrections in stereotactic radiation therapy treatment of the lung2012

    • Author(s)
      Akino Y ., Teshima T ., et al
    • Organizer
      ASTRO 54th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20120000
  • [Book] 5.放射線治療施設の運営・管理に関連する知識, 放射線治療部門の運営, 臨床放射線腫瘍学, 編集 日本放射線腫瘍学会2012

    • Author(s)
      手島昭樹
    • Total Pages
      183-188
    • Publisher
      日本放射線腫瘍学研究機構

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Published: 2015-06-25  

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