2013 Fiscal Year Final Research Report
Towards Elucidation of a novel mechanism for Pathogenesis of coagulation and fibrinolysis abnormalities in liver transplantation
| Project/Area Number |
23390313
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
UEMOTO Shinji 京都大学, 医学(系)研究科(研究院), 教授 (40252449)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Yasuhiro 名古屋大学, 医学部附属病院, 病院准教授 (20335251)
HATA Koichiro 京都大学, 大学院・医学研究科, 助教 (90523118)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 肝移植 / 血栓性微小血管症 / ADAMTS13 / 補体 / 血小板減少 |
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| Research Abstract |
Thrombotic microangiopathy (TMA) is one of the life threatening diseases, which characterized by aggregation of platelets in systemic circulation, and therefore multiple organ dysfunction. The purpose of this study is to clarify the clinical characteristics and prognostic factors of TMA after liver transplantation (LTx). A total of 290 LTx patients from April 2006 to March 2013 were evaluated. We elucidated that the ADAMTS13 activity decreased by more than half in all patients and that TMA is an inevitable process after LTx because of cold-ischemia/warm-reperfusion (CI/WR) during graft preservation. Pathological Confirmation revealed that sinusoidal injury after CI/WR activated complement system, thus regulation of complement activation could be the target to improve the early outcome after LTx.
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