2013 Fiscal Year Final Research Report

Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses

Research Project

Project/Area Number	23390314
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	Kagoshima University
Principal Investigator	YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
Co-Investigator(Kenkyū-buntansha)	SAHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 准教授 (90452333) OKU Manei 鹿児島大学, 医学部歯学部付属病院, 医員 (50550000) SHIMIZU Akira 日本医科大学, 医学部, 教授 (00256942)
Project Period (FY)	2011-04-01 – 2014-03-31
Keywords	小腸移植 / ミニブタ / 組織適合性抗原 / GvH / キメラ
Research Abstract	With this grant support, we have successfully established a survival orthotopic intestinal transplantation procedure in MHC-inbred CLAWN miniature swine. To our knowledge, this is the first successful long term, life supporting preclinical intestinal transplantation model in Japan. Our results demonstrated (1 ) compartment syndrome following heterotopic intestine transplantation in CLAWN miniature swine, (2) greater than 3 months acceptance of a life-supporting intestinal grafts, and (3) severe and acute inflammatory cytokine storm in the induction period as well as a strategy to inhibit the cytokine storm (manuscript in preparation).

(2 results)