2013 Fiscal Year Final Research Report
Development of novel bio-therapy using hybrid peptide against intrahepatic cholangiocarcinoma
| Project/Area Number |
23390318
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
YANAGAWA Toru 東京女子医科大学, 医学部, 講師 (00338980)
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
YAMAMOTO Masakazu 東京女子医科大学, 医学部, 教授 (60220498)
KAWAKAMI Koji 京都大学, 医学系研究科, 教授 (70422318)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 胆道系悪性腫瘍 / 分子標的治療 / ハイブリッドペプチド / サイトカイン / 受容体 |
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| Research Abstract |
It is known that the interleukin-4 receptor alpha (IL-4R alpha) is highly expressed on the surface of various human solid tumors. We have newly designed IL-4R alpha-lytic hybrid peptide composed of binding peptide to IL-4R alpha and cell-lytic peptide. Here, we evaluated the antitumor activity of the IL-4R alpha-lytic hybrid peptide as a novel molecular targeted therapy in human biliary tract cancer (BTC) cells. IL-4R alpha-lytic hybrid peptide showed cytotoxic activity in siz BTC cell lines with a concentration that killed 50% of all cells (IC50) as low as 5 micromoles/L. In addition, intravenous administration of IL-4R alpha-lytic hybrid peptide significantly inhibited tumor growth in a xenograft model of human BTC in vivo. Taken together, these results indicated that the IL-4R alpha-lytic hybrid peptide is a potent agent that might provide a novel therapy for patients with BTC.
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Research Products
(59 results)
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[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress2014
Author(s)
Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T
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Journal Title
J Dermatol Sci
Volume: 74
Pages: 9-17
Peer Reviewed
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2014
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Y amato M, Kadota S, T akeuchi K, Ishikawa A, Onodera M, Onizawa K, Y amamoto M, Miyoshi E, Shoda, J
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Peer Reviewed
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[Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, T okushige K, Hashimoto E, Utsunomiya H, T akahashi H, Ishii T, Y amamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Pages: 620-32
Peer Reviewed
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[Journal Article] Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma2013
Author(s)
Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shinkai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H
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Journal Title
J Proteomics
Volume: 85
Pages: 1-11
Peer Reviewed
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[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
Author(s)
Harada H, Warabi E, Matsuki T, Y anagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
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Journal Title
J Neuroscience
Volume: 33
Pages: 14767-14777
Peer Reviewed
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[Journal Article] Negative expression of N-acetylglucosamyltransfererase V in oral squamous cell carcinoma correlates with poor prognosis2013
Author(s)
Seto K, Uchida F, Baba O, Y amatoji M, Karube R, Warabi E, Y anagawa T, Onizawa K, Miyoshi E, Shoda J, Bukawa H
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, T okushige K, Ueda T, Harada N, T aguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Y amamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47
Pages: 924-35
Peer Reviewed
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[Journal Article] Potent In V itro and In V iv o Antitumor Activity of Sorafenib Against Human Intrahepatic Cholangio- carcinoma Cells2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, T akeuchi K, Onodera M, Nakanuma Y, Y amato M, Y amamoto M, Hyodo I, Shoda J
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
Peer Reviewed
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[Presentation] 肝内胆管癌の新規糖蛋白質マーカーの開発2013
Author(s)
小貫建一郎, 樋口亮太, 谷澤武久, 梶山英樹, 川本徹, 山本雅一, 中沼安二, 大河内信弘, 松田厚志, 久野 敦, 成松 久, 正田純一
Organizer
第49回胆道学会
Place of Presentation
千葉
Year and Date
20130919-20
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