2013 Fiscal Year Final Research Report
Development of new reagent for liver diseases using S1P and hyaluronic acid
| Project/Area Number |
23390319
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUNAGA Kiyoshi 筑波大学, 医学医療系, 講師 (20361339)
TAMURA Tamura 筑波大学, 医学医療系, 講師 (20633192)
KOBAYASHI Akihiko 筑波大学, 医学医療系, 講師 (10446552)
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| Co-Investigator(Renkei-kenkyūsha) |
MURATA Soichiro 筑波大学, 医学医療系, 准教授 (40436275)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 肝再生 / 血小板 / 線維化抑制 / 肝硬変 / S1P |
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| Research Abstract |
We previously reported that platelets have ability of liver regeneration and liver protection. Sphingosine 1 phosphate (S1P) is the main component of this ability. In this study, we revealed that S1P directly activates liver sinusoidal endothelial cells. In addition, we generated new drug delivery system (DDS) using hyaluronic acid (HA) which is selectively incorporated into liver sinusoidal endothelial cells. The new reagent by adapting S1P and HA ameliorated rat ischemia-reperfusion injury of the liver.
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[Journal Article] Platelet-derived adenosine 5' - triphosphate suppresses activa tion of human hepatic stellate cell - in vitro study -2012
Author(s)
Ikeda N, Murata S, Maruyama T, Tamu ra T, Nozaki R, Kawasaki T, Fukunag a K, Oda T, Sasaki R, Homma M, Ohko hchi N
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Journal Title
Hepatol Res
Volume: 42(1)
Pages: 91-102
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