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2013 Fiscal Year Final Research Report

Development of novel method to control chronic rejection after lung transplantation using suppression of IL-6 amplifier

Research Project

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Project/Area Number 23390334
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

OKUMURA Meinoshin  大阪大学, 医学(系)研究科(研究院), 教授 (40252647)

Co-Investigator(Kenkyū-buntansha) MINAMI Masato  大阪大学, 医学部附属病院, 准教授 (10240847)
INOUE Masayoshi  大阪大学, 医学系研究科, 准教授 (10379232)
SAWABATA Noriyoshi  大阪大学, 医学系研究科, 招聘教授 (50403184)
SHINTANI Yasushi  大阪大学, 医学系研究科, 講師 (90572983)
NAKAGIRI Tomoyuki  大阪大学, 医学系研究科, 招聘教員 (70528710)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords肺移植 / 拒絶反応 / 免疫抑制 / IL-6 amplifier / EGF
Research Abstract

Lung transplantation has been established as the curative treatment for chronic progressive severe respiratory failure. Rejection of the graft is, however,most common in lung transplantation and graft survival is the poorest among all the organ transplantations. Therefore, suppression of rejection is essential to improve the long-term outcome of lung transplantation. We showed that Th17 cells induced by IL-6 play an important role in bronchiolitis obliterans (BO) which is supposed to the result of chronic rejection after lung transplantation.
In the present study, we further clarified that IL-6 amplifier, EGF, and CCL2 BO are involved in initiation of BO in the animal model as well as the clinical specimens. These results are supposed to lead to innovation of the novel method to suppress chronic rejection after lung transplantation.

  • Research Products

    (4 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation2013

    • Author(s)
      Lee J, Nakagiri T, kamimura D, Harada M, Oto T, Susaki Y, Shintani Y, Inoue M, Miyoshi S, Morii E, Hirano T, Murakami M, Okumura M
    • Journal Title

      International Immunology

      Volume: 25 Pages: 319-332

    • Peer Reviewed
  • [Journal Article] 心肺移植の適応・術式・成績2013

    • Author(s)
      奥村明之進, 澤芳樹
    • Journal Title

      移植

      Volume: 48巻 Pages: 192-200

  • [Journal Article] IL-6 amplifier NF- к B-triggered positive feedback for IL-6 signaling in grafts is involved in allogeneic rejection responses2012

    • Author(s)
      Lee J, Nakagiri T, Oto T, Harada M, Morii E, Shintani Y, Inoue M, Iwakura Y, Miyoshi S, Okumura M, Hirano T, Murakami M
    • Journal Title

      Journal of Immunology

      Volume: 189 Pages: 1928-1936

    • Peer Reviewed
  • [Presentation] Current status of lung transplantation in Japan2013

    • Author(s)
      Okumura M
    • Organizer
      Congress of the Asian Society of Transplantation
    • Place of Presentation
      Kyoto
    • Year and Date
      20130905-07

URL: 

Published: 2015-06-25  

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