2013 Fiscal Year Final Research Report
Mechano-signal transduction against 3-D mechanical stress in human connective tissue cells and MCS
| Project/Area Number |
23390363
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
NAKATA Ken 大阪大学, 医学(系)研究科(研究院), 教授 (00283747)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | メカニカルストレス / 三次元組織 / 運動器組織 / 軟骨細胞 / 半月板細胞 / 滑膜細胞 / メカノトランスダクション |
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| Research Abstract |
The effects and mechanism of cyclic mechanical stimulation against three dimensional cultured tissues from chondrocytes, synovial cells, meniscus cells, MC3T3, C2C12 cells were investigated. mRNA levels of PGE2 and metalloproteinases genes such as MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 were upregulated after three dimensional cyclic mechanical stimulation. Pharmaceutical drugs of Dexamethason, NSAIDs, hyaluronic acids have the suppressive effects on these transient gene upregulation. IL-1b and IL-6 signals were involved these mechanical signal transduction.
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[Journal Article] Analysis of displacement and deformation of the medial meniscus with a horizontal tear using a three-dimensional computer model2014
Author(s)
Amano H, Iwahashi T, Suzuki T, Mae T, Nakamura N, Sugamoto K, Shino K, Yoshikawa H, Nakata K
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Journal Title
Knee Surgery, Sports Traumatology, Arthroscopy
Volume: (in press)
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[Presentation] 関節鏡視下半月板縫合術2013
Author(s)
中田研, 前 達雄, 米谷泰一, 松尾 知彦, 橘優太, 中村憲正, 堀部秀二, 史野根生, 吉川秀樹
Organizer
第8 6回日本整形外科学術総会
Place of Presentation
広島
Year and Date
20130500
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Author(s)
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Organizer
第57回(公社)日本口腔外科学会総会・学術大会
Place of Presentation
横浜
Year and Date
20121000
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Author(s)
金銅真世, 北圭介, 前達雄, 松尾知彦, 下村和範, 室井悠里, 太田啓介, 赤峯勇哲, 覚道健治, 吉川秀樹, 中田研
Organizer
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Place of Presentation
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Year and Date
20121000
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Author(s)
太田啓介, 北圭介, 下村和範, 松尾知彦, 宮本諭, 金銅真世, 室井悠里, 前達雄, 覚道健治, 吉川秀樹, 中田研
Organizer
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Place of Presentation
東京
Year and Date
20120700
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