Fundamental researches to presentation a new animal models and the therapy development of the osteoarthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390369
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kagoshima University
• Principal Investigator: IJIRI KOSEI 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (00315417)
• Co-Investigator(Kenkyū-buntansha): SETSURO Komiya 鹿児島大学, 医歯学総合研究科, 教授 (30178371) ; HARUTOSHI Sakakima 鹿児島大学, 医学部, 教授 (10325780) ; SATOSHI Nagano 鹿児島大学, 医歯学総合研究科, 助教 (50373139)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 関節病学 / GADD45β / C/EBPβ / 変形性関節症

Outline of Final Research Achievements

Osteoarthritis (OA) is defined as a disease of cartilage, which causes the pain and disability in older adults. Our previous study suggested that Growth arrest and DNA damage-inducible protein 45 β (GADD45β) is overexpressed in chondrocyte clusters in OA cartilage, especially in early stage of progression. CCAAT enhancer binding protein (C/EBP) β is expressed in hypertrophic zone of murine growth plate and with a function in synergy with Gadd45β. Our studies suggested that C/EBPβ plays a central role in controlling GADD45β gene expression in articular chondrocytes and suggest that the interplay between C/EBPβ and GADD45β constitutes a feedback loop with implications in cartilage degradation and osteophyte formation in OA.

Free Research Field

医歯薬学