2014 Fiscal Year Final Research Report
Fundamental researches to presentation a new animal models and the therapy development of the osteoarthritis
Project/Area Number |
23390369
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kagoshima University |
Principal Investigator |
IJIRI KOSEI 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (00315417)
|
Co-Investigator(Kenkyū-buntansha) |
SETSURO Komiya 鹿児島大学, 医歯学総合研究科, 教授 (30178371)
HARUTOSHI Sakakima 鹿児島大学, 医学部, 教授 (10325780)
SATOSHI Nagano 鹿児島大学, 医歯学総合研究科, 助教 (50373139)
|
Project Period (FY) |
2011-04-01 – 2015-03-31
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Keywords | 関節病学 / GADD45β / C/EBPβ / 変形性関節症 |
Outline of Final Research Achievements |
Osteoarthritis (OA) is defined as a disease of cartilage, which causes the pain and disability in older adults. Our previous study suggested that Growth arrest and DNA damage-inducible protein 45 β (GADD45β) is overexpressed in chondrocyte clusters in OA cartilage, especially in early stage of progression. CCAAT enhancer binding protein (C/EBP) β is expressed in hypertrophic zone of murine growth plate and with a function in synergy with Gadd45β. Our studies suggested that C/EBPβ plays a central role in controlling GADD45β gene expression in articular chondrocytes and suggest that the interplay between C/EBPβ and GADD45β constitutes a feedback loop with implications in cartilage degradation and osteophyte formation in OA.
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Free Research Field |
医歯薬学
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