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2013 Fiscal Year Final Research Report

Development of novel therapies for cancer pain based on supraspinal mechanisms

Research Project

  • PDF
Project/Area Number 23390374
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionShinshu University

Principal Investigator

KAWAMATA Tomoyuki  信州大学, 医学部, 准教授 (80336388)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Daisuke  信州大学, 医学部, 助教(特定雇用) (40467189)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords骨がん痛
Research Abstract

Bone cancer pain is often debilitating, difficult to treat, and insufficiently relieved. In this study, we examined the supraspinal mechanisms of intractable bon cancer pain. To clarify the supraspinal mechanisms, we focused on amygdala and descending pain inhibitory system. We found that persistent intractable bone cancer pain did not affect he functions of amygdala and descending pain inhibitory system. since we reported that bone cancer induced the functional changes of spinal neurons and peripheral neurons, the results of this study indicate that peripheral and spinal nervous systems rather than supraspinal system splay an important role in development and maintenance of bone cancer pain.

  • Research Products

    (26 results)

All 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (10 results) (of which Invited: 1 results) Book (6 results)

  • [Journal Article] 外套細胞より供給されるL-セリンに注目した化学療法誘起末梢神経障害の機序2013

    • Author(s)
      川股知之, 木谷友洋
    • Journal Title

      日薬理誌

      Volume: 141 Pages: 71-75

    • Peer Reviewed
  • [Journal Article] がん性腹膜炎による難治性疼痛の病態解析2013

    • Author(s)
      鈴木雅美, 成田 年, 川股知之, 的場元弘, 上園保仁
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 255-262

  • [Journal Article] がんの神経浸潤と痛みにおけるがん細胞と神経のクロストーク2013

    • Author(s)
      鈴木雅美, 川股知之, 成田 年, 上園保仁
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 625-63

  • [Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice2012

    • Author(s)
      Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashizawa M, Miyano K, Yanagihara K, Chiwaki F, Suzuki T, Matoba M, Sasaki H, Uezono Y
    • Journal Title

      Anesthesiology

      Volume: 117 Pages: 847-56

    • Peer Reviewed
  • [Journal Article] 疼痛治療の薬理学-末梢から脊髄への痛みの伝達2012

    • Author(s)
      川股知之
    • Journal Title

      BRAIN MEDICAL

      Volume: 90 Pages: 7-12

  • [Journal Article] がん疼痛の発生メカニズム2012

    • Author(s)
      川真田樹人, 川股知之
    • Journal Title

      薬局

      Volume: 63 Pages: 15-20

  • [Journal Article] 骨転移痛のメカニズムと鎮痛薬による薬物療法2012

    • Author(s)
      川股知之, 布施谷仁志, 山本克己, 石田高志, 平林高暢, 川真田樹人
    • Journal Title

      ペインクリニック

      Volume: 33 Pages: 1353-60

    • Peer Reviewed
  • [Journal Article] Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy2011

    • Author(s)
      Kiya T, Kawamata T, Namiki A, Yamakage M
    • Journal Title

      Neuroscience

      Volume: 174 Pages: 190-199

    • Peer Reviewed
  • [Journal Article] 癌性疼痛の発生機序2011

    • Author(s)
      川股知之, 山本克己, 布施谷仁志, 平林高暢, 坂本明之, 川真田樹人
    • Journal Title

      麻酔

      Volume: 60巻 Pages: 1010-17

    • Peer Reviewed
  • [Journal Article] がん疼痛を科学する2011

    • Author(s)
      川股知之
    • Journal Title

      麻酔増刊

      Volume: 60巻 Pages: S177-S182

  • [Presentation] がんの痛みのメカニズム2012

    • Author(s)
      川股知之
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20120607-09
    • Invited
  • [Presentation] Role of satellite cell-derived L-serine in the dorsal root ganglionin paclitaxel-induced peripheral neuropathy2012

    • Author(s)
      Kawamata T
    • Organizer
      The 85th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Kyoto
    • Year and Date
      20120314-16
  • [Presentation] aCGRP is involved in inflammation- but not incision-induced thermal hyperalgesia2011

    • Author(s)
      Ishida K, Kawamata T, Shindo T, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] Involvement of phopholipaseCb and TRPV1 in inflammation-induced thermal hyperalgesia2011

    • Author(s)
      Ide S, Kawamata T, Shimizu F, Mochidome M, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] Behavioral characterization of a newly developed model of postoperative pain after laparotomy2011

    • Author(s)
      Tanaka H, Kawamata T, Sugiyama D, Ichino T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] A low concentration of levobupivacaine has a potent differential sensory blocking property2011

    • Author(s)
      Sakamoto A, Tanaka S, Kawamata T, Tsukahara Y, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] TRPV1 and TRPV2 are expressed in primary afferent neurons innervating bone marrow2011

    • Author(s)
      Yamamoto K. Kawamata T, Ishida K, Sakamoto A, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] Possible involvement of monoaminergic control of motoneurons in mechanically compressed spinal cord injury-induced spasticity2011

    • Author(s)
      Mochiduki N, Kawamata T, Tanaka S, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] QX314 selectively reduces ongoing pain but not movement-evoked pain in a murine model of bone cancer pain2011

    • Author(s)
      Fuseya S, Kawamata T, Imai E, Urasawa S, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      20111015-19
  • [Presentation] 骨がん疼痛におけるTRPV1陽性末梢神経の関与.シンポジウム「がん患者のQuality of Life を向上させるための基礎から臨床への橋渡し研究-その基盤を支える薬理学研究」2011

    • Author(s)
      川股知之
    • Organizer
      日本薬理学会
    • Place of Presentation
      横浜
    • Year and Date
      20110322-24
  • [Book] 薬物療法. VIII. 骨粗鬆症の疼痛管理. 最新の骨粗鬆症学-骨粗鬆症最新の知見2013

    • Author(s)
      川股知之
    • Total Pages
      421-425
    • Publisher
      東京, 日本臨牀社
  • [Book] ①骨転移. 2.がん性痛. VI. 痛みの原因と鎮痛薬の選択. 痛みのScience & Practice第3巻 痛みの薬物治療(山本達郎編)2013

    • Author(s)
      布施谷仁志, 川股知之
    • Total Pages
      248-251
    • Publisher
      東京, 文光堂
  • [Book] ②がんによる神経障害性痛. 2.がん性痛. VI. 痛みの原因と鎮痛薬の選択. 痛みのScience & Practice 第3巻 痛みの薬物治療(山本達郎編)2013

    • Author(s)
      川股知之
    • Total Pages
      252-255
    • Publisher
      東京, 文光堂
  • [Book] 2.骨転移痛. I.がん疼痛の発生機序と治療. 病態疾患別がん性疼痛の治療 (井関雅子編)2013

    • Author(s)
      川股知之
    • Total Pages
      30-33
    • Publisher
      東京, 文光堂
  • [Book] 末梢神経でのmu オピオイド受容体発現と鎮痛効果.I.鎮痛機序.第2 章 ペインクリニック・緩和医療. 垣花 学・成田 年編.オピオイド 基礎を知って臨床で使いこなす2012

    • Author(s)
      川股知之
    • Total Pages
      141-57
    • Publisher
      克誠堂出版, 東京
  • [Book] 2.骨痛の緩和療法.IV.骨痛のメカニズムと緩和療法.米田俊之編.がん骨転移のバイオロジーとマネージメント2012

    • Author(s)
      川股知之
    • Total Pages
      248-53
    • Publisher
      医薬ジャーナル社, 東京

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Published: 2015-06-25  

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