2013 Fiscal Year Final Research Report
Identification of genetic polymorphisms associated with onset of neuropathic pain and therapeutic efficacy
| Project/Area Number |
23390377
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (60281656)
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| Co-Investigator(Kenkyū-buntansha) |
ARITA Hideko 日本大学, 医学部, 兼任講師 (10114357)
KASAI Shinya 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
ISEKI Masako 順天堂大学, 医学部, 臨床教授 (80221076)
FUKUDA Kenichi 東京歯科大学, 歯学部, 准教授 (80228907)
NISHIZAWA Daisuke 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主任研究員 (80450584)
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| Co-Investigator(Renkei-kenkyūsha) |
ARINAMI Tadao 筑波大学, 人間総合科学研究科, 教授 (10212648)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 神経障害性疼痛 / ゲノムワイド関連研究 / 発症脆弱性 / 遺伝子多型 / オーダーメイド医療 / 抗がん剤 / 末梢神経障害 / 治療薬反応性 |
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| Research Abstract |
Huge individual differences in vulnerability to neuropathic pain and in responsibility to its therapy hamper effective therapy for neuropathic pain. In the present study, we focused on bilateral sagittal split ramus osteotomy (BSSRO) which is a common orthognatic surgical procedure and causes peripheral nerve disturbances in some patients and not in the others. We conducted genome wide association study in 360 patients and found associations between genetic polymorphisms located in the ARID1B and ZPLD1 genes and hypoesthesia and between a genetic polymorphism in the METTL4 gene and dysesthesia.
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[Journal Article] Genome-wide association study identifies a potent locus associated with human opioid sensitivity2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K
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Journal Title
Mol Psychiatry
Volume: 19
Pages: 55-62
DOI
Peer Reviewed
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[Journal Article] Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity2013
Author(s)
Yamamoto H, Kamegaya E, Sawada W, Hasegawa R, Yamamoto T, Hagino Y, Takamatsu Y, Imai K, Koga H, Mishina M Ikeda K
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Mol Brain
Volume: 6
Pages: 56
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Peer Reviewed
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[Journal Article] Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene2013
Author(s)
Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Ozaki N, Nabeshima T, Miyamoto Y, Nitta A
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Journal Title
PLoS ONE
Volume: 8(10)
Pages: e76960
DOI
Peer Reviewed
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[Journal Article] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus2013
Author(s)
Shinohara M, Saitoh M, Nishizawa D, Ikeda K, Hirose S, Takanashi J, Takita J, Kikuchi K, Kubota M, Yamanaka G, Shiihara T, Kumakura A, Kikuchi M, Toyoshima M, Goto T, Yamanouchi H, Mizuguchi M
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Journal Title
Neurology
Volume: 80
Pages: 1571-1576
DOI
Peer Reviewed
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Author(s)
Ohara A, Kasahara Y, Yamamoto H, Hata H, Kobayashi H, Numachi Y, Miyoshi I, Hall FS, Uhl GR, Ikeda K, Sora I
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Journal Title
Biochem Biophys Res Commun
Volume: 432
Pages: 526-532
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Peer Reviewed
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[Journal Article] Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderly Japanese2012
Author(s)
Ella E, Sato N, Nishizawa D, Kageyama S, Yamada H, Kurabe N, Ishino K, Tao H, Tanioka F, Nozawa A, Chen R, Shinmura K, Ikeda K, Sugimura H
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Journal Title
J Hum Genet
Volume: 57
Pages: 385-390
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Peer Reviewed
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[Journal Article] Haplotype analysis of GSK-3beta gene polymorphisms in bipolar disorder lithium responders and non-responders
Author(s)
Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, Onozawa Y, Nagahori K, Fukamauchi F, Ikeda K, Ishigooka J
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Journal Title
Clinical Neuropharmacology
Volume: (in press)
Peer Reviewed
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