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2013 Fiscal Year Final Research Report

The role of lipid metabolism in prostate cancer

Research Project

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Project/Area Number 23390378
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionGunma University

Principal Investigator

SUZUKI Kazuhiro  群馬大学, 医学(系)研究科(研究院), 教授 (80312891)

Co-Investigator(Kenkyū-buntansha) ITO Kazuto  群馬大学, 医学系研究科, 准教授 (00302472)
SEKINE Yoshitaka  群馬大学, 医学系研究科, 助教 (00516370)
MATSUI Hiroshi  群馬大学, 重粒子線医学推進機構, 講師 (40450374)
KOIKE Hidekazu  群馬大学, 医学部, 講師 (90420091)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords前立腺癌 / 脂質
Research Abstract

Various basic studies were conducted to elucidate the effect of lipids on prostate cancer. First, squalene synthase, which is the key enzyme in mevalonate pathway is evaluated. Our previous study revealed that the SNP of FDFT1, which encodes squalene synthase, was associated with risk of prostate cancer development. The present study showed that down-regulation of FDFT1 gene expression led to significant inhibition of cancer proliferation. Furthermore, the FDFT1 gene expression levels were correlated with biological aggressiveness of prostate cancer. Next, the effect of statin was evaluated as to LDL receptor. Prostate cancer cells were the target of statin. Statin regulated both LDL receptor expression profiles and cholesterol content in the cell. These regulatory events were relevant to prostate cancer proliferation. Finally, the effect of metformin was evaluated. Metformin inhibit prostate cancer proliferation via down-regulation of IGF1-receptor.

  • Research Products

    (19 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results)

  • [Journal Article] Androgen receptor coactivator p120 subtype β is highly expressed in prostate cancer2013

    • Author(s)
      Muramatsu K, Matsui H, Sekine Y, Koike H, Shibata Y, Ito K, Suzuki K
    • Journal Title

      Prostate Int

      Volume: 1(1) Pages: 10-5

    • Peer Reviewed
  • [Journal Article] Development of prostate cancer in a patient with primary hypogonadism : intratumoural steroidogenesis in prostate cancer tissues2013

    • Author(s)
      Arai S, Shibata Y, Nakamura Y, Kashiwagi B, Uei T, Tomaru Y, Miyashiro Y, Honma S, Hashimoto K, Sekine Y, Ito K, Sasano H, Suzuki K
    • Journal Title

      Andrology

      Volume: 1(1) Pages: 169-74

    • Peer Reviewed
  • [Journal Article] Diagnostic significance of [-2]pro-PSA and prostate dimension-adjusted PSA-related indices in men with total PSA in the 2.0-10.0 ng/mL range2013

    • Author(s)
      Ito K, Miyakubo M, Sekine Y, Koike H, Matsui H, Shibata Y, Suzuki K
    • Journal Title

      World J Urol

      Volume: 31(2) Pages: 305-11

    • Peer Reviewed
  • [Journal Article] Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer2012

    • Author(s)
      Fukuma Y, Matsui H, Koike H, Sekine Y, Shechter I, Ohtake N, Nakata S, Ito K, Suzuki K
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 15(4) Pages: 339-45

    • Peer Reviewed
  • [Journal Article] Luteinizing hormone (LH)-releasing hormone agonist reduces serum adrenal androgen levels in prostate cancer patients : implications for the effect of LH on the adrenal glands2012

    • Author(s)
      Nishii M, Nomura M, Sekine Y, Koike H, Matsui H, Shibata Y, Ito K, Oyama T, Suzuki K
    • Journal Title

      J Androl

      Volume: 33(6) Pages: 1233-8

    • Peer Reviewed
  • [Journal Article] Rapamycin enhances docetaxel-induced cytotoxicity in a androgen-independent prostate cancer xenograft model by survivin downregulation2012

    • Author(s)
      Morikawa Y, Koike H, Sekine Y, Matsui H, Shibata Y, Ito K, Suzuki K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419(3) Pages: 584-9

    • Peer Reviewed
  • [Journal Article] Development and external validation of a nomogram for predicting cancer probability at initial prostate biopsy using the life expectancy-and prostate volume-adjusted biopsy scheme2012

    • Author(s)
      Nomura M, Ito K, Miyakubo M, Sekine Y, Tamura Y, Shimizu N, Aoki S, Suzuki K
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 15(2) Pages: 202-9

    • Peer Reviewed
  • [Journal Article] Impact of pretreatment factors, biopsy Gleason grade volume indices and post-treatment nadir PSA on overall survival in patients with metastatic prostate cancer treated with step-up hormonal therapy2012

    • Author(s)
      Miyamoto S, Ito K, Miyakubo M, Suzuki R, Yamamoto T, Suzuki K, Suzuki K, Yamanaka H
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 15(1) Pages: 75-86

    • Peer Reviewed
  • [Presentation] Statin inhibits Progression of Human Prostate Androgen Independent Cancer Cells via Regulating miRNA Expressions2014

    • Author(s)
      Sekine Y, Furuya Y, Kato H, Miyazawa Y, Syuto T, Arai S, Nitta T, Koike H, Matsuhi H, Shibata Y, Ito K, Suzuki K
    • Organizer
      4th Asian Pacific Prostatic Society
    • Place of Presentation
      名護市
    • Year and Date
      20140321-22
  • [Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor2014

    • Author(s)
      Kato H, Sekine Y, Miyazawa Y, Syuto T, Furuya Y, Matsui H, Koike H, Suzuki K
    • Organizer
      4th Asian Pacific Prostatic Society
    • Place of Presentation
      名護市
    • Year and Date
      20140321-22
  • [Presentation] Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor2014

    • Author(s)
      Kato H, Sekine Y, Miyazawa Y, Furuya Y, Koike H, Suzuki K
    • Organizer
      AACR Prostate cancer meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2014-01-19
  • [Presentation] LH-RHアゴニストによる前立腺癌患者の血清副腎性アンドロゲン濃度の低下 : LHの副腎に対する作用への影響2013

    • Author(s)
      西井昌弘, 野村昌史, 関根芳岳, 小池秀和, 松井 博, 柴田康博, 羽鳥基明, 伊藤一人, 鈴木和浩, 小山徹也
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-04-28
  • [Presentation] アンドロゲンレセプターコアクチベーターp120のサブタイプβは前立腺癌で高発現する2013

    • Author(s)
      村松和道, 松井 博, 関根芳岳, 小池秀和, 柴田康博, 伊藤一人, 羽鳥基明, 野村昌史, 新田貴士
    • Organizer
      101回日本泌尿器科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-04-26
  • [Presentation] ホルモン不応性前立腺癌における, スタチンによる腫瘍内アンドロゲン de novo合成への影響の解明2013

    • Author(s)
      関根芳岳, 古谷洋介, 加藤春雄, 宮澤慶行, 新井誠二, 村松和道, 新田貴士, 小池秀和, 松井 博, 柴田康博, 伊藤一人, 鈴木和浩
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-04-25
  • [Presentation] Effects of LH-RH agonist on hormonal and cognitive function of prostate cancer patients in relation to testicular and adrenal androgens2012

    • Author(s)
      Suzuki K
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer symposium
    • Place of Presentation
      金沢市
    • Year and Date
      2012-11-17
  • [Presentation] Evaluation of adrenal androgens and estrogen levels in the prostatic tissue with prostate cancer or benign prostatic hyperplasia2012

    • Author(s)
      Arai S, Miyashiro Y, Shibata Y, Tomaru Y, Kobayashi M, Honma S and Suzuki K
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢市
    • Year and Date
      2012-11-16
  • [Presentation] 前立腺癌患者における脂肪組織でのアンドロゲン代謝の検討2012

    • Author(s)
      柴田康博, 新井誠二, 小池秀和, 松井 博, 本間誠次郎, 鈴木和浩
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-04-21
  • [Presentation] Androgen production in periprostatic adipose tissue in prostate cancer patients2012

    • Author(s)
      Shibata Y, Arai S, Koike H, Matsui H, Ito K, Honma S and Suzuki K
    • Organizer
      27th Annual EAU Congress
    • Place of Presentation
      Paris, France
    • Year and Date
      2012-02-27
  • [Presentation] 脂肪組織内におけるアンドロゲン合成酵素の遺伝子発現解析およびアンドロゲン定量2011

    • Author(s)
      新井誠二, 柴田康博, 本間誠次郎, 鈴木和浩
    • Organizer
      日本アンドロロジー学会第30回学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-23

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Published: 2015-06-25  

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