2013 Fiscal Year Final Research Report
The role of lipid metabolism in prostate cancer
Project/Area Number |
23390378
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Gunma University |
Principal Investigator |
SUZUKI Kazuhiro 群馬大学, 医学(系)研究科(研究院), 教授 (80312891)
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Co-Investigator(Kenkyū-buntansha) |
ITO Kazuto 群馬大学, 医学系研究科, 准教授 (00302472)
SEKINE Yoshitaka 群馬大学, 医学系研究科, 助教 (00516370)
MATSUI Hiroshi 群馬大学, 重粒子線医学推進機構, 講師 (40450374)
KOIKE Hidekazu 群馬大学, 医学部, 講師 (90420091)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | 前立腺癌 / 脂質 |
Research Abstract |
Various basic studies were conducted to elucidate the effect of lipids on prostate cancer. First, squalene synthase, which is the key enzyme in mevalonate pathway is evaluated. Our previous study revealed that the SNP of FDFT1, which encodes squalene synthase, was associated with risk of prostate cancer development. The present study showed that down-regulation of FDFT1 gene expression led to significant inhibition of cancer proliferation. Furthermore, the FDFT1 gene expression levels were correlated with biological aggressiveness of prostate cancer. Next, the effect of statin was evaluated as to LDL receptor. Prostate cancer cells were the target of statin. Statin regulated both LDL receptor expression profiles and cholesterol content in the cell. These regulatory events were relevant to prostate cancer proliferation. Finally, the effect of metformin was evaluated. Metformin inhibit prostate cancer proliferation via down-regulation of IGF1-receptor.
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[Journal Article] Development of prostate cancer in a patient with primary hypogonadism : intratumoural steroidogenesis in prostate cancer tissues2013
Author(s)
Arai S, Shibata Y, Nakamura Y, Kashiwagi B, Uei T, Tomaru Y, Miyashiro Y, Honma S, Hashimoto K, Sekine Y, Ito K, Sasano H, Suzuki K
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Journal Title
Andrology
Volume: 1(1)
Pages: 169-74
Peer Reviewed
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[Presentation] Statin inhibits Progression of Human Prostate Androgen Independent Cancer Cells via Regulating miRNA Expressions2014
Author(s)
Sekine Y, Furuya Y, Kato H, Miyazawa Y, Syuto T, Arai S, Nitta T, Koike H, Matsuhi H, Shibata Y, Ito K, Suzuki K
Organizer
4th Asian Pacific Prostatic Society
Place of Presentation
名護市
Year and Date
20140321-22
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[Presentation] ホルモン不応性前立腺癌における, スタチンによる腫瘍内アンドロゲン de novo合成への影響の解明2013
Author(s)
関根芳岳, 古谷洋介, 加藤春雄, 宮澤慶行, 新井誠二, 村松和道, 新田貴士, 小池秀和, 松井 博, 柴田康博, 伊藤一人, 鈴木和浩
Organizer
第101回日本泌尿器科学会総会
Place of Presentation
札幌市
Year and Date
2013-04-25
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