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2013 Fiscal Year Final Research Report

The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results

Research Project

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Project/Area Number 23390403
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKumamoto University

Principal Investigator

TANIHARA Hidenobu  熊本大学, 生命科学研究部, 教授 (60217148)

Co-Investigator(Kenkyū-buntansha) INOUE Toshihiro  熊本大学, 医学部附属病院, 講師 (00317025)
KAWAJI Takahiro  熊本大学, 医学部附属病院, 講師 (30423677)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords緑内障 / サイトカイン / 房水
Research Abstract

The concentrations of IL-8, MCP-1, EGF and PDGF-AA were elevated in the glaucomatous aqueous humor. The history of cataract surgery affected the aqueous MCP-1 concentraiotn, which was the highest among the cytokines. MCP-1 treatment changed the intracellular localization of ZO-1, increased permeability of the monolayer of Schlemm's canal endothelial cells, and increased aqueous outflow. MCP-1 expressed in the rabbit iris and ciliary body, and phacoemulsification surgery increased its expression in the cornea, iris and ciliary body transiently, while the surgery induced time-dependent increase of its expression only in the lens capsule. We confirmed the MCP-1 expression in the lens epithelial cells after surgery. These results indicate that aqueous MCP-1 may be involved in the glaucoma pathology.

  • Research Products

    (45 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (22 results) Remarks (1 results)

  • [Journal Article] Trabeculectomy for open-angle glaucoma in phakic eyes vs in pseudophakic eyes after phacoemulsification : a prospective clinical cohort study2014

    • Author(s)
      Takihara Y, Inatani M, Ogata-Iwao M, Kawai M, Inoue T, Iwao K, Tanihara H
    • Journal Title

      JAMA Ophthalmology

      Volume: 132 Pages: 69-76

    • DOI

      10.1001/jamaophthalmol.2013.5605

    • Peer Reviewed
  • [Journal Article] Epithelial mesenchymal transition-like phenomenon in trabecular meshwork cells2014

    • Author(s)
      Takahashi E, Inoue T, Fujimoto T, Kojima S, Tanihara H
    • Journal Title

      Experimental Eye Research

      Volume: 118 Pages: 72-79

    • DOI

      10.1016/j.exer.2013.11.014

    • Peer Reviewed
  • [Journal Article] Tear fluid signs associated with filtration blebs, as demonstrated by three-dimensional anterior segment optical coherence tomography2014

    • Author(s)
      Kojima S, Inoue T, Kawaji T, Tanihara H
    • Journal Title

      Clinical Ophthalmology

      Volume: 8 Pages: 767-772

    • DOI

      10.2147/OPTH.S59778

    • Peer Reviewed
  • [Journal Article] Long-term outcomes and prognostic factors for trabeculectomy with mitomycin C in eyes with uveitic glaucoma : a retrospective cohort study2014

    • Author(s)
      Iwao K, Inatani M, Seto T, Takihara Y, Ogata-Iwao M, Okinami S, Tanihara H
    • Journal Title

      Journal of Glaucoma

      Volume: 23 Pages: 88-94

    • DOI

      10.1097/IJG.0b013e3182685167

    • Peer Reviewed
  • [Journal Article] Long-term outcomes and complications of trabeculectomy for secondary glaucoma in patients with familial amyloidotic polyneuropathy2014

    • Author(s)
      Kawaji T, Inoue T, Hara R, Eiki D, Ando Y, Tanihara H
    • Journal Title

      PLoS One

      Volume: 9 Pages: e96324

    • DOI

      10.1371/journal.pone.0096324

    • Peer Reviewed
  • [Journal Article] Japanese Phaco-Goniosynechialysis Multicenter Study Group. Long-term efficacy of goniosynechialysis combined with phacoemulsification for primary angle closure2013

    • Author(s)
      Kameda T, Inoue T, Inatani M, Tanihara H
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 251 Pages: 825-830

    • DOI

      10.1007/s00417-012-2091-8

    • Peer Reviewed
  • [Journal Article] A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C2013

    • Author(s)
      Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H
    • Journal Title

      Acta Ophthalmologica

      Volume: 91 Pages: e500-501

    • DOI

      10.1111/aos.12133

    • Peer Reviewed
  • [Journal Article] Risk factors for choroidal detachment after trabeculectomy with mitomycin C2013

    • Author(s)
      Haga A, Inatani M, Shobayashi K, Kojima S, Inoue T, Tanihara H
    • Journal Title

      Clinical Ophthalmology

      Volume: 7 Pages: 1417-1421

    • DOI

      10.2147/OPTH.S46375

    • Peer Reviewed
  • [Journal Article] Study on prognostic factor in trabeculectomy with mitomycin C having history of previous glaucoma surgery2013

    • Author(s)
      Awai-Kasaoka N, Inoue T, Inatani M, Takihara Y, Ogata-Iwao M, Tanihara H
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 57 Pages: 514-519

    • DOI

      10.1007/s10384-013-0257-5

    • Peer Reviewed
  • [Journal Article] Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma2013

    • Author(s)
      Inoue T, Kawaji T, Tanihara H
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 54 Pages: 5353-5358

    • DOI

      10.1167/iovs.13-12245

    • Peer Reviewed
  • [Journal Article] Frequency and risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy2013

    • Author(s)
      Goto A, Inatani M, Inoue T, Awai-Kasaoka N, Takihara Y, Ito Y, Fukushima M, Tanihara H
    • Journal Title

      Journal of Glaucoma

      Volume: 22 Pages: 572-576

    • DOI

      10.1097/IJG.0b013e31824d514a

    • Peer Reviewed
  • [Journal Article] The effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on aqueous humor outflow facility2012

    • Author(s)
      Tsuboi N, Inoue T, Kawai M, Inoue-Mochita M, Fujimoto T, Awai-Kasaoka N, Yoshida A, Tanihara H
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 6702-6707

    • DOI

      10.1167/iovs.12-10376

    • Peer Reviewed
  • [Journal Article] Elevated levels of monocyte chemoattractant protein-1 in the aqueous humor after phacoemulsification2012

    • Author(s)
      Kawai M, Inoue T, Inatani M, Tsuboi N, Matsukawa A, Yoshida A, Tanihara H
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 7951-7960

    • Peer Reviewed
  • [Journal Article] Precise identification of filtration openings on the scleral flap by three-dimensional anterior segment optical coherence tomography2012

    • Author(s)
      Inoue T, Matsumura R, Kuroda U, Nakashima KI, Kawaji T, Tanihara H
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 8288-8294

    • DOI

      10.1167/iovs.12-10941

    • Peer Reviewed
  • [Journal Article] Impact of phacoemulsification on failure of trabeculectomy with mitomycin C2012

    • Author(s)
      Awai-Kasaoka N, Inoue T, Takihara Y, Kawaguchi A, Inatani M, Ogata-Iwao M, Tanihara H
    • Journal Title

      Journal of Cataract and Refractive Surgery

      Volume: 38 Pages: 419-424

    • DOI

      10.1016/j.jcrs.2011.09.035

    • Peer Reviewed
  • [Journal Article] A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma2012

    • Author(s)
      Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H
    • Journal Title

      J Biol Chem

      Volume: 287(30) Pages: 25395-406

    • DOI

      10.1074/jbc.M112.370130

    • Peer Reviewed
  • [Journal Article] The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells2012

    • Author(s)
      Kameda T, Inoue T, Inatani M, Fujimoto T, Honjo M, Kasaoka N, Inoue-Mochita M, Yoshimura N, Tanihara H
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 3092-3103

    • DOI

      10.1167/iovs.11-8018

    • Peer Reviewed
  • [Journal Article] Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor of pseudophakic glaucomatous eyes2012

    • Author(s)
      Inoue T, Kawaji T, Inatani M, Kameda T, Yoshimura N, Tanihara H
    • Journal Title

      Journal of Cataract and Refractive Surgery

      Volume: 38 Pages: 1389-1397

    • DOI

      10.1016/j.jcrs.2012.04.028

    • Peer Reviewed
  • [Journal Article] Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy2012

    • Author(s)
      Inoue T, Inatani M, Takihara Y, Awai-Kasaoka N, Ogata-Iwao M, Tanihara H
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 56 Pages: 1389-1397

    • DOI

      10.1007/s10384-012-0171-2

    • Peer Reviewed
  • [Journal Article] Monocyte chemotactic protein-1 level in the aqueous humor as a prognostic factor for the outcome of trabeculectomy

    • Author(s)
      Inoue T, Kawaji T, Tanihara H
    • Journal Title

      Clinical and Experimental Ophthalmology

      Volume: (in press)

    • DOI

      10.1111/ceo.12204

    • Peer Reviewed
  • [Journal Article] Filtration bleb revision guided by three-dimensional anterior segment optical coherence tomography

    • Author(s)
      Kojima S, Inoue T, Kawaji T, Tanihara H
    • Journal Title

      Journal of Glaucoma

      Volume: (in press)

    • DOI

      10.1097/IJG.0b013e3182741ee6

    • Peer Reviewed
  • [Journal Article] Risk factors for hyphema after trabeculectomy with mitomycin C

    • Author(s)
      Kojima S, Inatani M, Shobayashi K, Haga, A, Inoue T, Tanihara H
    • Journal Title

      Journal of Glaucoma

      Volume: (in press)

    • DOI

      10.1097/IJG.0b013e3182741c85

    • Peer Reviewed
  • [Presentation] Investigation of multiple proinflammatory cytokines in the aqueous humor in eyes with secondary glaucoma2013

    • Author(s)
      Inoue T, Tanihara H
    • Organizer
      World Glaucoma Congress 2013
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20130717-20
  • [Presentation] Short-term prospective investigation of filtering bleb by three dimensional anterior-segment optical coherence tomography2013

    • Author(s)
      Kojima S, Inoue T, Nakashima K, Fukushima A, Tanihara H
    • Organizer
      World Glaucoma Congress 2013
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20130717-20
  • [Presentation] Investigation of multiple proinflammatory cytokines in the aqueous humor in eyes with secondary glaucoma2013

    • Author(s)
      Inoue T, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      20130505-09
  • [Presentation] Short-term prospective investigation of filtering bleb by three dimensional anterior-segment optical coherence tomography2013

    • Author(s)
      Kojima S, Inoue T, Nakashima K, Fukushima A, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      20130505-09
  • [Presentation] Identification of TGF-β2-induced proinflammatory cytokines secreted from cultured trabecular meshwork cells2013

    • Author(s)
      Inoue-Mochita M, Inoue T, Fujimoto T, Awai-Kasaoka N, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      20130505-09
  • [Presentation] Evaluation of filtering blebs with transconjunctival oozing by anterior segment optical coherence tomography2013

    • Author(s)
      Nakashima K, Inoue T, Fukushima A, Hirakawa S, Kawaji T, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      20130505-09
  • [Presentation] 3D AS-OCT を用いたトラベクレクトミー術後濾過胞の評価2012

    • Author(s)
      小島祥, 井上俊洋, 川路隆博, 谷原秀信
    • Organizer
      第23回日本緑内障学会
    • Place of Presentation
      金沢 石川県立音楽堂
    • Year and Date
      20120928-30
  • [Presentation] 線維柱帯切除術後症例における3 次元前眼部OCT による房水漏出点の同定2012

    • Author(s)
      松村理世, 井上俊洋, 黒田詩子, 中島圭一, 川路隆博, 谷原秀信
    • Organizer
      第23回日本緑内障学会
    • Place of Presentation
      金沢 石川県立音楽堂
    • Year and Date
      20120928-30
  • [Presentation] Pinpoint identification of filtration opening on the scleral flap margins created by trabeculectomy2012

    • Author(s)
      Inoue T, Kawaji T, Matsumura R, Kuroda U, Nakashima K, Tanihara H
    • Organizer
      European Glaucoma Society 2012
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      20120617-22
  • [Presentation] Involvement of RhoA/Rho-associated kinase signal transduction pathway in the dexamethasone-induced alterations in aqueous outflow2012

    • Author(s)
      Fujimoto T, Inoue T, Inoue-Mochita M, Kameda T, Kasaoka N, Tanihara H
    • Organizer
      European Glaucoma Society 2012
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      20120617-22
  • [Presentation] The effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on the aqueous humor outflow facility2012

    • Author(s)
      Tsuboi N, Inoue T, Fujimoto T, Inoue-Mochita M, Kasaoka N, Kawai M, Shobayashi K, Yoshida A, Tanihara H
    • Organizer
      European Glaucoma Society 2012
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      20120617-22
  • [Presentation] Filtration bleb-associated tear film sign demonstrated by three dimensional anterior segment optical coherent tomography2012

    • Author(s)
      Kojima S, Inoue T, Kawaji T, Tanihara H
    • Organizer
      European Glaucoma Society 2012
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      20120617-22
  • [Presentation] Multiplex immunoassay of aqueous humor in cataract patients : impact of phacoemulsification2012

    • Author(s)
      Kawai M, Inoue T, Inatani M, Tsuboi N, Yoshida A, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      20120506-10
  • [Presentation] Pinpoint identification of filtration opening on the scleral flap margins created by trabeculectomy2012

    • Author(s)
      Tanihara H, Inoue T, Kawaji T, Matsumura R, Kuroda U, Nakashima K
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      20120506-10
  • [Presentation] The effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on the aqueous humor outflow facility2012

    • Author(s)
      Tsuboi N, Inoue T, Fujimoto T, Inoue-Mochita M, Kasaoka N, Kawai M, Shobayashi K, Yoshida A, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      20120506-10
  • [Presentation] A prospective study of phakic vs pseudophakic eyes after phacoemulsification in trabeculectomy for open-angle glaucoma2012

    • Author(s)
      Takihara Y, Inatani M, Iwao M, Kawai M, Inoue T, Iwao K, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      20120506-10
  • [Presentation] Filtration bleb-associated tear film sign demonstrated by three dimensional anterior segment optical coherence tomography2012

    • Author(s)
      Kojima S, Inoue T, Kawaji T, Kuroda U, Nakashima K, Matsumura R, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      20120506-10
  • [Presentation] Filtration bleb revision guided by three-dimensional anterior segmental optical coherence tomography2012

    • Author(s)
      Kojima S, Inoue T, Kawaji T, Tanihara H
    • Organizer
      The 27th APAO Congress
    • Place of Presentation
      Pusan, Korea
    • Year and Date
      20120413-16
  • [Presentation] 開放隅角緑内障の線維柱帯切除術 : 有水晶体眼と超音波乳化吸引術既往眼との前向き比較2012

    • Author(s)
      瀧原祐史, 稲谷大, 岩尾美奈子, 川井基史, 井上俊洋, 岩尾圭一郎, 谷原秀信
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京 国際フォーラム
    • Year and Date
      20120405-08
  • [Presentation] 開放隅角緑内障における房水内MCP-1 濃度が線維柱帯切除術の手術成績に与える影響2011

    • Author(s)
      井上俊洋, 稲谷大, 亀田隆範, 吉村長久, 谷原秀信
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田 ビューホテル
    • Year and Date
      20110923-25
  • [Presentation] 開放隅角緑内障に対するトラベクレクトミー単独手術と超音波水晶体乳化吸引術同時手術との前向き比較研究2011

    • Author(s)
      稲谷大, 岩尾美奈子, 瀧原祐史, 井上俊洋, 岩尾圭一郎, 谷原秀信
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田 ビューホテル
    • Year and Date
      20110923-25
  • [Presentation] The effect of aqueous monocyte chemotactic protein-1 concentration on the short-term failure of trabeculectomy with mitomycin C in eyes with open-angle glaucoma2011

    • Author(s)
      Inoue T, Inatani M, Kameda T, Yoshimura N, Tanihara H
    • Organizer
      World Glaucoma Congress 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      20110629-02
  • [Remarks]

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/ganka/kyousitu/gyouseki.html

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Published: 2015-06-25  

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